The 140th Annual Meeting of the Pharmaceutical Society of Japan (Kyoto)
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Session Details

Symposium

[S04]Notch signaling: context dependency, niche, and diseases

Thu. Mar 26, 2020 9:00 AM - 11:00 AM JST
Thu. Mar 26, 2020 12:00 AM - 2:00 AM UTC
[Room D] Room D 1F
Organizers: Motoyuki Itoh (Grad Sch Pharm, Chiba Univ), Takashi Minami (Inst Res Dev Anal, Kumamoto Univ)
The Notch signaling pathway is highly conserved among species and regulates progenitor proliferation, differentiation, and alternate cell fate choice in a variety of tissues during development. In addition to its roles at developmental stages, the Notch signaling pathway also plays critical roles in organ homeostasis and pathogenesis in adults. Recent studies have revealed many instances of the roles and regulations for Notch signaling. However, there remain many unexplored questions, especially regarding organ/tissue-dependent microenvironment or pathological conditions-dependent roles and the precise regulation for the treatment of Notch-related diseases. In this symposium, our selected speakers will show recent advances in understanding the Notch signaling in different context-dependent pathological phenomena with neurons, cardiovascular, immune systems, muscle systems, and malignant cancers.
9:00 AM - 9:05 AM JST(12:00 AM - 12:05 AM UTC)

[S04-Opening]Opening remarks/Introduction

Motoyuki Itoh1 (1. Grad Sch Pharm, Chiba Univ)
9:05 AM - 9:20 AM JST(12:05 AM - 12:20 AM UTC)

[S04-1]Functions and regulation of Notch signaling during neural development and brain diseases

○Motoyuki Itoh1 (1. Grad Sch Pharm, Chiba Univ)
9:20 AM - 9:40 AM JST(12:20 AM - 12:40 AM UTC)

[S04-2]NOTCH signaling as a therapeutic target for acute leukemia

○Shuji Tohda1 (1. Grad Sch Med, Tokyo Med Dent Univ)
9:40 AM - 10:00 AM JST(12:40 AM - 1:00 AM UTC)

[S04-3]Dll1 and Dll4 differently require their extracellular domains for triggering Notch signaling

○Katsuto Hozumi1 (1. Dept Immunol, Tokai Univ Sch Med)
10:00 AM - 10:20 AM JST(1:00 AM - 1:20 AM UTC)

[S04-4]Roles of Notch signaling in regulating muscle plasticity and regeneration

○Shin Fujimaki1, Tomohiro Matsumoto1, Yusuke Ono1 (1. Dept Muscle Dev Regeneration, Kumamoto Univ)
10:20 AM - 10:40 AM JST(1:20 AM - 1:40 AM UTC)

[S04-5]Significance of Notch signaling and downstream genes in cardiovascular development and disease

○Osamu Nakagawa1, Yusuke Watanabe1, Akihiro Urasaki1 (1. Nat'l Cerebr Cardiovasc Ctr)
10:40 AM - 10:55 AM JST(1:40 AM - 1:55 AM UTC)

[S04-6]Notch-mediated vascular sprouting and the maturation in health and disease

○Takashi Minami1,2 (1. Div Mol Vasc Biol, Inst Res Dev Anal, Kumamoto Univ, 2. Grad Sch Pharm Sci, Kumamoto Univ)
10:55 AM - 11:00 AM JST(1:55 AM - 2:00 AM UTC)

[S04-Closing]Summary/Closing remarks

Takashi Minami1 (1. Inst Res Dev Anal, Kumamoto Univ)
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