The 140th Annual Meeting of the Pharmaceutical Society of Japan (Kyoto)
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Session Details

Symposium

[S15]Research frontiers on viral infection and antiviral therapy -drug discovery and development based on new concepts-

Thu. Mar 26, 2020 4:15 PM - 6:15 PM JST
Thu. Mar 26, 2020 7:15 AM - 9:15 AM UTC
[Room D] Room D 1F
Organizers: Yasumasa Iwatani (Clinical Research Center, National Hosp Organization Nagoya Medical Center), Hirokazu Tamamura (Inst Biomat Bioeng, Tokyo Med Dent Univ), Shogo Misumi (Global Cent Nat Res Sci, Kumamoto Univ)
Recent research & development (R&D) based on novel concepts and multidisciplinary pharmaceutical information have brought new effective therapeutic drugs for virus infection. For example, the mechanistic concept of new anti-HIV integrase inhibitors, which has greatly improved the prognosis of HIV-infected people, was applied to development of the new anti-influenza virus drug as a "chelate" drug. Thus, there has been a great focus on multidisciplinary R&D beyond a virus target, utilizing such novel mechanistic concepts. Here, in this session, five scientists present their unique studies on novel antiviral drugs of which the concepts are highly applicable across the fields: 1) a new strategy against membrane fusion upon HIV infection, 2) anti-influenza virus drug, Baloxavir, 3) anti-HIV RNaseH inhibitor, 4) new compound targets against Kaposi's sarcoma-associated herpesvirus infection, 5) latency-reversing agents for a new HIV-cure approach. With maximized utilization of their unique concepts, the presentations will aid us for further development of novel therapeutic drugs for virus infection as well as other diseases that is not related to virus infection.
4:15 PM - 4:21 PM JST(7:15 AM - 7:21 AM UTC)

[S15-Opening]オーガナイザー挨拶

岩谷 靖雅1 (1. 国立病院名古屋医療セ臨床研セ)
4:21 PM - 4:43 PM JST(7:21 AM - 7:43 AM UTC)

[S15-1]Inhibitors targeting conformational change of HIV envelope proteins

○Hirokazu Tamamura1 (1. Inst. Biomat. Bioeng., Tokyo Med. Dent. Univ.)
4:43 PM - 5:05 PM JST(7:43 AM - 8:05 AM UTC)

[S15-2]Development of the inhibitors for HIV-1 reverse transcriptase RNase H activity

○Tyuji Hoshino1 (1. Grad. Schl. Pharm. Sci., Chiba Univ.)
5:05 PM - 5:27 PM JST(8:05 AM - 8:27 AM UTC)

[S15-3]Discovery of baloxavir marboxil, cap-dependent endonuclease inhibitor

○Takeshi Noshi1 (1. Shionogi & Co., Ltd.)
5:27 PM - 5:49 PM JST(8:27 AM - 8:49 AM UTC)

[S15-4]Recent progress on the research and discovery of drugs and molecular targets of Kaposi's sarcoma-associated herpesvirus

○Tadashi Watanabe1 (1. Kyoto Pharmaceutical University)
5:49 PM - 6:10 PM JST(8:49 AM - 9:10 AM UTC)

[S15-5]Towards an HIV Cure: activation of latent provirus reservoirs with Kumamoto University natural product library

○Shogo Misumi1 (1. Global Center for Natural Resources Sciences, Kumamoto University)
6:10 PM - 6:15 PM JST(9:10 AM - 9:15 AM UTC)

[S15-Closing]総括

三隅 将吾1 (1. 熊大院薬グローバル天然物科学研究セ)
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