Session Details
[26P-am]ケミカルバイオロジー①／天然物・生体由来医薬品／医薬品設計・構造活性相関①
Thu. Mar 26, 2020 9:00 AM - 11:30 AM JST
Thu. Mar 26, 2020 12:00 AM - 2:30 AM UTC
Thu. Mar 26, 2020 12:00 AM - 2:30 AM UTC
[Room P] Event Hall 1F
[26P-am091S]Development of organic chemical reaction for detection of
N1-methyladenosine
○Takuya Kamikawa1, Tomoya Hirano2, Hiroyuki Kagechika1 (1. Inst. Biomat. Bioeng., Tokyo Med. Dent. Univ, 2. Osaka Univ. Pharm. Sci.)
[26P-am092S]Development of the photoremorable protective group activatable under bio-environments.
○Daiki Kato1, Erika Yamazaki1, Tomoya Hirano2, Hiroyuki Kagechika1 (1. Inst. Biomat. Bioeng., Tokyo Med. Dent. Univ, 2. Osaka Univ. Pharm. Sci.)
[26P-am093S]Design and synthesis of CDN analogs targeting STING
○Yuta Yanase1,3, Kentaro Ikeda2,3, Genichiro Tsuji3, Norihito Shibata3, Mikihiko Naito3, Yosuke Demizu3,2 (1. Med. life Sci., Yokohama city Univ., 2. Grad. Sch. Med. life Sci., Yokohama city Univ., 3. NIHS)
[26P-am094]Development of peptide-based inducers of nuclear receptor degradation
○YOKOO HIDETOMO1,2, Nobumichi Ohoka1, Mikihiko Naito1, Yousuke Demizu1,2 (1. National Institute of Health Sciences, 2. Grad. Sch. Med Life Sci., Yokohama City Univ.)
[26P-am095]Development of cell-penetrating peptides having disubstituted amino acids based on Pep-1 sequence
○Takuma Kato1, Mihoko Nakamachi1, Akiko Asano1, Mitsunobu Doi1 (1. Osaka Univ. Pharm. Sci.)
[26P-am096]Cell-penetrating cyclic peptides library and Screening system using ribosome display
○Toshihiro Shikakura1, Hiroshi Kita1, Hirofumi Maeda1, Keishi Takatsu1, Mitsuaki Kitano1 (1. kaneka)
[26P-am097]Mechanism of inhibition of cancer cell growth by leucinostatin A analog, a modulator of tumor-stroma interaction
○Hikaru Abe1, Tomokazu Ohishi2, Chiharu Sakashita1, Saqib Uzama3, Baig Mirzza S.3, Shun-ichi Ohba2, Hiroyuki Inoue2, Takumi Watanabe1, Manabu Kawada1, Masakatsu Shibasaki1 (1. BIKAKEN, 2. BIKAKEN Numazu Branch, 3. Indian Institute of Technology)
[26P-am098]Development of antiganase with hydrolyzing R2 region in tau protein
○Hiroaki Taguchi1, Taminao Ito1, Yuki Kato1, Emi Hifumi2, Taizo Uda3,4 (1. Pharm. Sci., Suzuka Univ. Med. Sci., 2. Res. Promo. Inst., Oita UNIV, 3. Sci. Tech., Oita UNIV, 4. ISIT)
[26P-am099S]Ivermectin binding protein(IvBP) is a druggable mediator of the Wnt/β-catenin pathway
○Honami Yonezawa1, Akari Ikeda2,3, Ryo Takahashi2, Tomoyasu Hirose2,3, Masato Iwatsuki2,3, Satoshi Omura3, Toshiaki Sunazuka2,3, Yoshimasa Uehara4, Naoyuki Nishiya1,4 (1. Grad. Sch. Pharm., Iwate Med. Univ., 2. Grad. Sch. Infect. Control Sci., Kitasato Univ., 3. Kitasato Inst. Life Sci., Kitasato Univ., 4. Sch. Pharm., Iwate Med. Univ.)
[26P-am100]Synthesis and target identification of chalcone derivatives showing effective cytotoxicity
against castration-resistant prostate cancer
○Yohei SAITO1, Atsushi MIZOKAMI1, Kouji IZUMI1, Renato NAITO1, Masuo GOTO2, Kyoko NAKAGAWA-GOTO1,2 (1. Grad. Sch. Pharm. Sci., Kanazawa Univ., 2. UNC)
[26P-am101]Study on melanogenesis inhibitory and antioxidant activity of plant extracts
○Ayana Hiki1, Naofumi Yamada2, Tsutomu Yamasaki1, Kenshin Nishimura1, Takaaki Saeki3, Toru Nakanishi2 (1. Dept.Pharm.,Shujitsu Univ., 2. Grad. Sch. Pharm. Sci., Shujitsu Univ., 3. Smile Co., Ltd)
[26P-am102S]Synthesis of novel anti-TB compounds based on the marine natural product
○Junya Mukomura1, Kazuhiro Nishioka1, Yoshiko Aoyagi1, Maho Kishimoto1, Masayoshi Arai2, Naoyuki Kotoku1 (1. Coll. Pharm. Sci., Ritsumeikan Univ., 2. Grad. Sch. Pharm. Sci., Osaka Univ.)
[26P-am103S]Effects of cell proliferation and differentiation in neural progenitor cells by nobiletin, a flavonoid compound contained in citrus fruits.
○MAYU YAMAZAKI1, TAKAHIRO HIRABAYASHI1, YUKI HASHIGUCHI1, JUNKO SHIBATOU1, YOSHIHIKO CHIBA1, FUMIKO TAKENOYA1, SEIJI SHIODA1 (1. Hoshi Univ.)
[26P-am104S]Synthesis of neural stem cells activator: lindbladione
○Yuna Makita1,2, Midori A. Arai1,2, Masami Ishibashi1,2 (1. Grad. Sch. Pharm. Sci., Chiba Univ., 2. Plant Mol. Sci. Cent., Chiba Univ.)
[26P-am105S]Synthesis of heterocyclic rocaglamide derivatives with TRAIL-resistance overcoming activity
○Yoshinori Makita1,2, Midori A. Arai1,2, Masami Ishibashi1,2 (1. Grad. Sch. Pharm. Sci., Chiba Univ., 2. Plant Mol. Sci. Cent., Chiba Univ.)
[26P-am106]Design, synthesis and glycosidase inhibition of broussonetine M , broussonetine W and their analogues
○Yuna Shimadate1, Atsushi Kato1, Kyoko Kinami1, Isao Adachi1 (1. Department of Hospital Pharmacy, University of Toyama )
[26P-am107]Difference of GAA mutation site affect to pharmacological chaperone effect of DNJ
○Shuki Imaeda1, Atsushi Kato1, Izumi Nakagome2, Shuichi Hirono2, Isao Adachi1 (1. Department of hospital pharmacy, University of Toyama, 2. School of pharmacy, Kitasato University)
[26P-am108]Characterization of anti-herpes simplex virus activity of monogalactosyl diacylglycerol (MGDG) isolated from a green alga, Coccomyxa sp. KJ
○Satoko Komatsu1, Kyoko Hayashi2, Hitoshi Kuno1, Mana Kanazashi1, Kinya Atsumi1, Toshimitsu Hayashi3, Toshio Kawahara3 (1. DENSO CORPORATION, 2. Grad. Sch. Tech., Chubu Univ., 3. Dept. Life and Health Sci., Chubu Univ.)
[26P-am109]Search for a potent inhibitor of hypoxia-induced HIF-1α protein accumulation from the soil fungus
Sho Takaki1, Emi Watanabe1, Miki Shinohara1, Eri Tsumoto1, Karin Hashimoto1, Tadahiro Etoh1, ○Yongpil Kim1 (1. Pharm., Iryososei Univ.)
[26P-am110]Mechanism of action of new anti-inflammatory compound from soil fungus targeting TLR signaling pathway
○Tadahiro Etoh1, Miki Shinohara1, Sho Takaki1, Eri Tsumoto1, Karin Hashimoto1, Emi Watanabe1, Yongpil Kim1 (1. Pharm., Iryososei Univ.)
[26P-am111S]Synthesis and cytotoxicity evaluation of kukoamine derivatives
○Asuka Aoyama1, Koichi Takao2, Hitoshi Kamauchi2, Yoshiaki Sugita2 (1. Grad. Sch. Pharm. Sci., Josai Univ., 2. Pharm. Sci., Josai Univ.)
[26P-am112S]Synthesis and neuroprotective effect of Gingerol derivatives.
○takumi oda1, koichi takao2, hitoshi kamauchi2, yoshiaki sugita2 (1. Grad. Sch. Pharm. Sci., josai Univ, 2. Pharm. Sci., josai Univ)
[26P-am113S]Structure-Activity Relationship Study of Matrine Type Alkaloid Part 36; Development of Analgesic through Kappa-Opioid Receptor by Focusing on Piperidine Derivatives Having heterocycle
○Mayu Kawamura1, Hiroaki Teramoto1, Masahiro Oono1, Chihiro Suzuki1, Yui Anzai1, Sigeru Sasaki1, Takayasu Yamauchi1, Kimio Higashiyama1 (1. Institute of Medicinal Chemistry, Hoshi University)
[26P-am114S]Structure-Activity Relationship of Matrine type Alkaloids Part;35 Syntheshis and Evaluation of Antinociception of 4-Arylpiperidine Derivatives
○Chihiro Suzuki1, Hiroaki Teramoto1, Masahiro Oono1, Mayu Kawamura1, Yui Anzai1, Shigeru Sasaki1, Takayasu Yamauchi1, Kimio Higashiyama1 (1. Institute of Medicinal Chemistry, Hoshi University)
[26P-am115S]Synthesis of morphinan derivatives selectively activating morphine-insensitive mu opioid receptor splice variants
○junichi niwa1, ayaka honjoh1, yonezawa yuh2, shigeto hirayama1, fumika karaki1, kennosuke itoh1, hirokazu mizoguchi2, hideaki fujii1 (1. Pharm., Kitasato Univ., 2. Pharm.,Tohoku Med Pharmaceut Univ.)
[26P-am116]Biological evaluation of SF5-functionalized Aryliodonium salts
○Etsuko Tokunaga1, Norimichi Saito2, Norio Shibata1 (1. Grad. Sch. Eng., Nagoya Inst. Tech., 2. Ube Ind.)
[26P-am117S]Design and synthesis of fluorine-containing naphthoquinones with antibacterial activity
○Ryuji Umeda1, Mitsuaki Yamashita1, Jun Sawano1, Ayuka Tatsumi1, Akira Iida1 (1. Faculty of Agriculture., Kindai Univ.)
[26P-am118S]Synthesis, biological activities and structure-activity relationship of curcumin analogs with phenolic functions
○Aoi Sugawara1, Toshika Ohashi2, Satoshi Ogawa2, Naomi Goto1, Mayumi Nakanishi-Matsui1, Satoru Tamura1, Tomikazu Kawano1 (1. Sch. Pharm. Iwate Medical Univ., 2. Iwate Univ.)
[26P-am119S]Construction of new scaffolds containing silicon atom based on terpenoids
○Soya Koremura1, Akihiro Sugawara1, Haruhisa Kikuchi1 (1. Grad. Sch. Pharm. Sci., Tohoku Univ.)
[26P-am120]Preparation and biological evaluation of stilbene derivatives of therapeutic agent for Alzheimer's disease
○Shinya Kimura1, Kosei Shimizu1, Ryuzou Abe1, Yoshimi Kitahara1, Natchanun Sirimangkalakitti1, Yoshihiro Kino1, Junichi Sato1, Naoki Saito1 (1. MPU)
[26P-am121]ß-Secretase inhibitory effects of flurbiprofen derivatives having triphenyl rings
○Narumi Katagiri1, Maiko Ohigashi1, Hiroaki Sasaki1, Naoki Yamakawa1 (1. Faculty of Pharmaceutical Sciences, Shujitsu University.)
[26P-am122]Membrane permeabilizing and COX inhibitory activity of flurbiprofen derivatives containing two fluorine atoms
○Sora Kobayashi1, Maiko Ohigashi1, Naoki Yamakawa1 (1. Faculty of Pharmaceutical Sciences, Shujitsu University.)
[26P-am123]Discovery of non-steroidal anti-inflammatory drugs for the treatment of dry eye disease
○Yui Morikuro1, Maiko Ohigashi1, Satoka Kasai2, Tohru Mizushima2, Naoki Yamakawa1 (1. Faculty of Pharmaceutical Sciences, Shujitsu University., 2. LTT Bio-Pharma CO., Ltd.)
[26P-am124]Study on E3 ligase-independent protein knockdown with target protein degrader using hydrophobictag system
○Takuji Shoda1, Nobumichi Ohoka1, Genichiro Tsuji1, Hideshi Inoue2, Mikihiko Naito1, Yosuke Demizu1 (1. Natl. Inst. Health Sci., 2. Tokyo Univ Pharm Life Sci)
[26P-am125]Design, synthesis and SARs of novel IDO1 inhibitors for cancer immunotherapy
○Naohisa Ogo1, Masaya Nonaka1, Momoko Ishihara1, Mito Watanabe1, Katsumi Ota1, Hisashi Murakami1, Osamu Takikawa2, Akira Asai1 (1. Grad. Div. Pharm. Sci., Univ. of Shizuoka, 2. AMED)
[26P-am126S]Design and synthesis of novel linker-payload with STLC derivative for ADCs
○Taiki Ichida1, Ryota Fukai1, Yumeka Ikeda1, Nao Miyoshi1, Naohisa Ogo1, Akira Asai1 (1. Grad. Div. Pharm. Sci., Univ. of Shizuoka)
[26P-am127]A quick synthesis of bithiazolophanes framework exhibiting an anti-c-Met activity and exploring the mechanism of the activity of bithiazolophane using SILCS
○Tatsuya Takimoto1, Hideaki Sasaki1, Hirohito Tsue2, Hiroki Takahashi2, Kouji Aoki1, Tatsuki Betsuyaku1, Kazuhito Hioki1, Ozge Yoluk3, Sunwan Jo4, Alexander D. Mackerell, Jr.3 (1. Fac. Pharm. Sci., Kobe Gakuin Univ., 2. Grad. Sch. Human and Env. Studies, Kyoto Univ., 3. Dept. Pharm. Sci., Sch. Pharm., Univ. of Maryland Baltimore, 4. SilcsBio, LLC)
[26P-am128S]Structure activity relationship study of ck2 inhibitors with a pyrazole scaffold by nitrogen scan
○Masateru Okumura1, Shinsuke Nakanishi1, Yasuna Kurimoto1, Keiji Nishiwaki1, Shinya Nakamura1, Shinya Oishi2, Hiroaki Ohno2, Isao Nakanishi1 (1. Grad. Sch. Pharm. Sci., Kindai Univ., 2. Grad. Sch. Pharm. Sci., Kyoto Univ.)
[26P-am129S]Structure activity relationship study of ck2 inhibitors having a pyrazole scaffold ~change of activity and solubility by replacing hydrogen with fluorine~
○Masaya Kugimiya1, Ryo Yamaguchi1, Keiji Nishiwaki1, Shinya Nakamura1, Isao Nakanishi1 (1. Sch. Pharm. Sci., kindai Univ.)
[26P-am130S]SAR study of CK2 inhibitors with a purine scaffold ~tautomerism of purine scaffold~
○Yuki Kawazu1, Eri Nakagawa1, Kenji Yoshioka1, Shinya Nakamura1, Keiji Nishiwaki1, Masato Tsuyuguchi2, Takayoshi Kinoshita2, Isao Nakanishi1 (1. Grad. Sch. Pharm. Sci., Kindai Univ., 2. Grad. Sch. Sci., Osaka Prefecture Univ.)
[26P-am131]Development of a novel fluorescence recovery assay to explore Polo-like kinase 1 type-I inhibitors
○Kohei Tsuji1,2, David Hymel2, Terrence Burke2 (1. IBB, TMDU, 2. NCI, NIH)
[26P-am132S]Design and synthesis of class II-selective histone deacetylase inhibitors
○Honoka Murakami1, Mitsuaki Yamashita1, Yuki Shimizu1, Teruyuki Tahara1, Shinya Hayakawa1, Akira Iida1 (1. Faculty of Agriculture, Kindai University)
[26P-am133]Design and synthesis of novel tropolone derivatives as xanthine oxidase (XO) inhibitors
○Kiminori Ohta1, Daisuke Sato2, Asako Kaise2, Yasuyuki Endo2 (1. Sch. Pharm., Showa Univ., 2. Fac. Pharm. Sci., Tohoku Med. Pharm. Univ.)
[26P-am134S]Synthetic studies of pemetrexed prodrugs aiming for the oral administration.
Kimachi Tetsutaro1, ○Kasumi Miyoshi1, Noboru Hayama1, Kiyofumi Inamoto1, Anna Miyazaki1, Akira Nakamura2, Tomohiro Maegawa2, Toru Ototi2, Kenji Matsuyama3 (1. Sch. Pharm. Sci., Mukogawa Women's Univ., 2. Faculty. Pharm. Sci., Kindai Univ., 3. Hanshin dispensing Pharmacy.)
[26P-am135]Diversity-Oriented Synthesis of Carbaglucose Derivatives for the Discovery of Novel SGLT Inhibitors
○Yoshiaki Kitamura1, Chiori Iwai1, Nanako Nagaya1, Erina Oba1, Hiroshi Katagiri2, Hiroshi Ueda1,3, Yukio Kitade1,4, Mahmoud Kandeel5, Masato Ikeda1,3,6 (1. Fac. Eng., Gifu Univ., 2. Grad. Sch. Sci. Eng., Yamagata Univ., 3. United Grad. Sch. Drug Discov. Med. Info. Sci., Gifu Univ., 4. Fac. Eng., Aichi Inst. Tech., 5. Fac. Vet. Med., Kafrelshiekh Univ., 6. Cent. Hig. Adv. Integ. Nano Life Sci., Gifu Univ.)
[26P-am136]Development of a cell-penetrating helical peptide for intracellular siRNA delivery
○Makoto Oba1, Kaori Furukawa1, Masakazu Tanaka1 (1. Grad. Sch. Biomed. Sci. Nagasaki Univ. )
[26P-am137]Structure-activity relationships study of derivatives containing the X-Pro-Arg repeat sequence of the antimicrobial peptide myticalin A6
○Keiko Okimura1, Keiko Matsubara1, Hanako Ito1, Rie Suzuki1 (1. Faculty of Pharm. Sci., Hokuriku Univ.)
[26P-am138S]Synthetic study of new analgesic opioid peptides with cage structure
○Ogaswara Sho1, Chigusa Seki1, Sinobu Sakurada2, Yuko Okuyama2, Koji Uwai1, Hiroto Nakano1 (1. Muroran Institute of Technology, 2. Tohoku Medical and Pharmaceutical University)
[26P-am139S]Synthetic studies of new analgestic small opioid peptides
○Ryouta Suzuki1, Chigusa Seki1, Koji Uwai1, Yuko Okuyama2, Hiroto Nakano1 (1. Muroran Institute of Technology, 2. Tohoku Medical and Pharmaceutical University)
[26P-am140]Synthesis and effects of the dimerization of a small peptidomimetic with hydrophilic linkers on anti-tumor activity
○Anna Miyazaki1, Hiyori Hase1, Noboru Hayama1, Kiyofumi Inamoto1, Koushi Hidaka2, Yuko Tsuda2, Nana Yamanouchi2, Shoji Fukushima2, Tetsutaro Kimachi1 (1. Sch. Pharm. and Pharm. Sci., Mukogawa Women's Univ., 2. Fac. Pharm. Sci., Kobe Gakuin Univ.)