Session Details
[27P-am]ケミカルバイオロジー②／医薬品設計・構造活性相関②／
Fri. Mar 27, 2020 9:00 AM - 11:30 AM JST
Fri. Mar 27, 2020 12:00 AM - 2:30 AM UTC
Fri. Mar 27, 2020 12:00 AM - 2:30 AM UTC
[Room P] Event Hall 1F
[27P-am001S]Development of Fe(II)-selective 19F-MRI probes in vivo
○Ryo Kakiuchi1, Tasuku Hirayama1, Mieko Tsuji1, Hideko Nagasawa1 (1. Gifu Pharm. Univ.)
[27P-am002S]Development and application of fluorogenic substrates independent of prodrugation for imaging intracellular GSTP1 activity
○Kodai Watanabe1, Yuuta Fujikawa1, Masaya Mori1, Megumi Sakata1, Hideshi Inoue1 (1. Sch. Life Sci., Tokyo Univ. Pharm. Life Sci.)
[27P-am003S]Single enzyme activity-based protein profiling - a methodology for ultra-sensitive detection of disease related alterations of enzymatic activities
○Shingo Sakamoto1, Toru Komatsu1, Rikiya Watanabe2, Yi Zhang3, Taiki Inoue1, Mitsuyasu Kawaguchi4, Hidehiko Nakagawa4, Takaaki Ueno5, Takuji Okusaka6, Kazufumi Honda7, Hiroyuki Noji3,8, Yasuteru Urano1,9,10 (1. Grad. Sch. Pharm. Sci., The Univ. Tokyo, 2. RIKEN, 3. Grad. Sch. Eng., The Univ. Tokyo, 4. Grad. Sch. Pharm. Sci., Nagoya City Univ., 5. Osaka Dent. Univ., 6. Natl. Cancer Ctr. Hosp., 7. Natl. Cancer Ctr. Res. Inst., 8. ImPACT, 9. Grad. Sch. Med., The Univ. Tokyo, 10. AMED-CREST)
[27P-am004S]Development of fluorescent LAT1 substrates for cancer imaging
○Ren Ito1, Mako Kamiya2, Yasuteru Urano1,2,3 (1. Grad. Sch. Pharm. Sci., Tokyo Univ., 2. Grad. Sch. Med., Tokyo Univ., 3. CREST, AMED)
[27P-am005S]Development and application of a fluorescent probe for detecting activity of neurolysins.
○Etsu Kyo1, Yuki Ichihashi1, Toru Komatsu1, Hiroyuki Matsuzaki2, Keisuke Hata2, Toshiaki Watanabe2, Yasuteru Urano1,2,3 (1. Grad. Sch. Pharm. Sci, Tokyo Univ., 2. Grad. Sch. Med. Sci, Tokyo Univ., 3. AMED-CREST)
[27P-am006S]Development of a fluorescent probe for detection of CYP3A4 activity in living cells
○Takayuki Ikeno1, Kenjiro Hanaoka11, Sayaka Deguchi2,4, Kazuo Takayama2,3,4, Hiroyuki Mizuguchi2,4,7,8, Yasuteru Urano1,5,6 (1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2. Graduate School of Pharmaceutical Sciences, Osaka University, 3. PRESTO, JST, 4. National Institutes of Biomedical Innovation, Health and Nutrition, 5. Graduate School of Medicine, The University of Tokyo, 6. CREST, AMED, 7. MEI Center, Osaka University, 8. OTRI, Osaka University)
[27P-am007]A novel selection methodology of peptide aptamers using photocrosslinking of nucleic acids
○Takuya Terai1, Tomoyuki Koike1, Naoto Nemoto1 (1. Grad. Sch. Sci. Eng., Saitama Univ.)
[27P-am008]An approach toward visual detection of single nucleotide polymorphism using double duplex invasion of peptide nucleic acid
○Moriya Shun-suke1, Yuko Sasa1, Keiko Kuwata2, Yasutada Imamura3, Yosuke Demizu4, Masaaki Kurihara5, Atsushi Kittaka1, Toru Sugiyama1 (1. Fac. of Pharm-Sciences, Teikyo Univ., 2. WPI-ITbM, Nagoya Univ., 3. Sch. of Adv. Eng., Kogakuin Univ., 4. Div. of Org. Chem., Nat. Inst. of Health Sci., 5. Dept. of Pharm. Sci., Inter. Univ. of Health and Welfare.)
[27P-am009]A combination of an artificial cationic oligosaccharide and phosphorothioated linkages strongly improves siRNA stability
○Atsushi Irie1, Kazuki Sato2, Rintaro Hara2,3, Takeshi Wada2, Futoshi Shibasaki1 (1. Tokyo Metro. Inst. Med. Sci., 2. Tokyo Univ. Sci., 3. Tokyo Med. Dent. Univ.)
[27P-am010S]Target identification by using a ligand-conjugated oligonucleotide and its complementary strand bearing a reactive group and a fluorescent unit
○Takumi Yoshida1, Takao Yamaguchi2, Satoshi Obika2 (1. Sch. Pharm. Sci., Osaka Univ., 2. Grad. Sch. Pharm. Sci., Osaka Univ.)
[27P-am011S]Development of chemically modified mRNA for mRNA medicine
○Kei Takebuchi1, Daisuke Kawaguchi1, Fumitaka Hashiya1, Kosuke Nakamoto1, Naoko Abe1, Hiroshi Abe1,2,3 (1. Grad. Sch. Sci., Nagoya Univ., 2. RIKEN, 3. JST CREST)
[27P-am012S]Synthetic study on carbocyclic-2'-deoxynucleoside
-synthesis of carbocyclic-2'-deoxy-7-deazaadenosine-
○Ayana Mizuishi1, Chiaki Saito1, Kotaro Meguro1, Akari Uematsu1, Toshiaki Harashima1, Hironori Hayashi2, Eiichi Kodama2, Takashi Misawa3, Yosuke Demizu3, Masaaki Kurihara1, Kiju Konno1 (1. School of Pharmacy, International University of Health and Welfare, 2. Tohoku University School of Medicine, 3. National Institute of Health Sciences)
[27P-am013S]Synthetic study on carbocyclic-2’-deoxynucleoside
-synthesis of carbocyclic-2’-deoxyuridine
○Chiaki Saito1, Ayana Mizuishi1, Kotaro Meguro1, Akari Uematsu1, Toshiaki Harashima1, Hironori Hayashi2, Eiichi Kodama2, Takashi Misawa3, Yosuke Demizu3, Masaaki Kurihara1, Kiju Konno1 (1. School of Pharmacy, International University of Health and Welfare, 2. Tohoku University School of Medicine, 3. National Institute of Health Sciences)
[27P-am014]Enhancement of insulin secretion by a novel adenosine analogue COA-Cl
○Ikuko Tsukamoto1, Akram Hossain1, Maki Takata1, Wenhua Liu2, Katsuya Hirano1, Yasuo Kubota1, Junsuke Igarashi3, Ryoji Konishi1 (1. Fac. of Med., Kagawa Univ., 2. Chinese Academy of Science, 3. Morinomiya Univ.of Med. Sci.)
[27P-am015S]Synthesis of the major metabolite M8 from ticagrelor and simultaneous determination of ticagrelor and M8 by a novel LC/MS method
○Momoko Suzuki1, Ryuichi Ogawa1, Kenichi Kobayashi1 (1. Grad. Sch. Pharm. Sci., Meiji Pharm. Univ.)
[27P-am016]Drug discovery of anti-influenza viral RNA-dependent RNA polymerase agents by targeting the PA–PB1 interaction
○Satoshi Mizuta1, Hiroki Otaki1, Ken Watanabe2 (1. Grad. Sch. Biomedical. Sci., Nagasaki Univ., 2. Yasuda Women's Univ.)
[27P-am017S]MD and FMO analyses of alkenyldiarylmethane as non-nucleic acid HIV-1 reverse transcriptase inhibitor.
○Takanori Takei1, Yuki Tanabe1, Mai Hiraoka1, Naoki Ito1, Jun Takayama1, Meiyan Xuan1, Mari Okazaki1, Takeshi Sakamoto1 (1. Fac. Pharm. Sci., Josai Univ.)
[27P-am018]Water-soluble prodrugs of HIV-1 protease inhibitor
○Yoshio Hamada1, Usui Kenji1 (1. Faculty of Frontier of Innovative Research in Science and Technology, Konan University)
[27P-am019S]Development of novel HIV entry inhibitor: structural optimization of oleanolic acid derivatives by aziridine-based conformational restriction
○Hiromu Suzuki1, Reon Takeuchi2, Shigeyoshi Harada3, Kohei Sato1,2, Nobuyuki Mase1,2, Tetsuo Narumi1,2 (1. Fac. Eng., Shizuoka Univ., 2. Grad. Sch. Integ. Sci. Tech., Shizuoka Univ., 3. NIID, AIDS Res. Cent. )
[27P-am020S]Design and synthesis of an aza-decalin type SARS 3CL protease inhibitor containing an amino-methyl substituent
○Chisato Takenaka1, Yuuho Shimizu1, Hayato Mitani1, Mitsuki Iwamoto1, Kouji Onishi1, Kazuya Kobayashi1, Yasunao Hattori2, Kenichi Akaji1 (1. Department of Medicinal Chemistry, Kyoto Pharmaceutical University, 2. Center for Instrumental Analysis, Kyoto Pharmaceutical University)
[27P-am021S]Synthetic study for an aryl-bridged macrocyclic BACE1 inhibitor
○Shino Utsumi1, Akiho Kimura1, Takuya Otani1, Kazuya Kobayashi1, Yasunao Hattori2, Kenichi Akaji1 (1. Department of Medicinal Chemistry, Kyoto Pharmaceutical University, 2. Center for Instrumental Analysis, Kyoto Pharmaceutical University)
[27P-am022S]The rerationship of radical scavenging ability and electrochemical properities in pharmacology
○Masato Kamibayashi1,2, Ikuo Nakanishi2 (1. Grad. Sch. Adv. Integration Sci., Chiba. Univ., 2. Natl. Inst. Radiol. Sci., Natl. Inst. Quant. Radiol. Sci.)
[27P-am023]Structural development of type 1 ryanodine receptor inhibitors based on a quinolone structure
○Shuichi Mori1, Hiroto Iinuma1, Noriaki Manaka1, Mari Ishigami-Yuasa1, Nagomi Kurebayashi2, Takashi Murayama2, Hiroyuki Kagechika2 (1. Inst. Biomat. Bioeng., Tokyo Med. Dent. Univ., 2. Department of Parmacology, Juntendo Univ. School of Medicine)
[27P-am024S]Development of type 2 ryanodine receptor inhibitors based on novel screening method for its channel activity
○Hiroto Iinuma1, Xikun Chai1, Shuichi Mori1, Mari Ishigami-Yuasa1, Nagomi Kurebayashi2, Takashi Murayama2, Hiroyuki Kagechika1 (1. Inst. Biomat. Bioeng., Tokyo Med. Dent. Univ, 2. Department of Pharmacology, Juntendo University School of Medicine)
[27P-am025]Structure development of nonsteroidal progesterone receptor ligands based on benzenesulfonamide scaffold
○Kazuki Otani1, Ayumi Yamada1, Shuichi Mori1, Shinya Fujii1, Hiroyuki Kagechika1 (1. Inst. Biomat. Bioeng., Tokyo Med. Dent. Univ.)
[27P-am026S]Development of novel 6-aryl quinolones as progesterone receptor antagonists
○Risa Sumida1, Mai Negishi1, Shuichi Mori2, Hiroyuki Kagechika2, Aya Tanatani1 (1. Grad. Sch. Adv. Sci., Ochanomizu Univ., 2. Inst. Biomater. Bioeng., Tokyo Med. Den. Univ.)
[27P-am027S]Structural expansion of lithocholic acid amide derivatives as vitamin D receptor agonist
○Ayana Yoshihara1, Haru Kawasaki1, Hiroyuki Masuno2, Emiko Kawachi2, Yasunari Kanda3, Naoya Hirata3, Nobutoshi Ito4, Hiroyuki Kagechika2, Aya Tanatani1 (1. Grad. Sch. Adv. Sci., Ochanomizu Univ., 2. Inst. Biomater. Bioeng., Tokyo Med. Den. Univ., 3. Nat. Inst. Health Sci., Jpn., 4. Med. Res. Inst., Tokyo Med. Den. Univ.)
[27P-am028]Syntheses of 2-(2-triazolylethyl)-1α,25-dihydroxy-19-norvitamin D3 and their metabolism
○Masashi Takano1, Kaori Yasuda2, Hiroki Mano2, Toshiyuki Sakaki2, Atsushi Kittaka1 (1. Fac. of Pharm. Sci., Teikyo Univ., 2. Fac. of Eng., Toyama Pref. Univ.)
[27P-am029]Research for evaluation of the interaction between co-factor peptide and vitamin D receptor
○Nami Ohashi1, Shiori Nagata1, Mami Yoshizawa1, Toshimasa Itoh1, Keiko Yamamoto1 (1. Showa Pharm.l Univ.)
[27P-am030]Synthesis of novel vitamin K derivatives with neuronal differentiation-inducing activity that mimiced the side chain structure of retinoic acid
Taiki Sato1, Mikino Arakawa2, Maya Kamao3, Akimori Wada4, Yoshihisa Hirota2, ○Yoshitomo Suhara1 (1. Lab. Org Synth. Med. Chem., Shibaura Inst. Tech., 2. Lab. Biochem., Shibaura Inst. Tech., 3. Ext. Center, Kobe Pharm. Univ., 4. Lab. Org. Chem. Life Sci., Kobe Pharm. Univ.)
[27P-am031]Exploration of estrogen receptor beta (ERβ) selective agonists
○Kensuke Misawa1, Shotaro Tsunoda1, Takayoshi Inoue1, Akira Hachiya1, Yoshiya Sugai1 (1. Kao Corp.)
[27P-am032S]Evaluation on subtype selectivity of selective estrogen receptor down-regulators containing a long alkyl chain
○Moena Tsuda1,2, Takuji Shoda2, Hideshi Inoue1, Yosuke Demizu2,3 (1. Sch. Life Sci., Tokyo Univ. Pharm. Life Sci., 2. NIHS, 3. Grad. Sch. Med. Life Sci., Yokohama city Univ.,)
[27P-am033S]Structure-activity relationships of novel indirubin derivatives on anticancer activity and polarity
○Rumiko Kojima1, Ayaka Kondo1, Niina Nakamura1, Kazuhiko Hayashi1, Shinichi Miyairi2, Yoshimi Ichimaru1,2 (1. Coll. Of Pharm., Kinjo Gakuin Univ., 2. Sch. Pharm., Nihon Univ.)
[27P-am034S]Re-evaluation of methoxyindirubins at 5- and 5'- substitution on anticancer activity
○Niina Nakamura1, Rumiko Kojima1, Ayaka Kondo1, Kazuhiko Hayashi1, Shinichi Miyairi2, Yoshimi Ichimaru1,2 (1. Coll. Of Pharm., Kinjo Gakuin Univ., 2. Sch. Pharm., Nihon Univ.)
[27P-am035]Biological Evaluation of Elongated Linker Containing Symmetric Boronic Acid Derivatives
○Kaori Ota1, Jian-Rong Zhou2, Kazumi Yokomizo2, Nobuhiro Kashige1, Makoto Furutachi1, Kunihiro Sumoto1 (1. Fukuoka University, 2. Sojo University)
[27P-am036]Synthesis and Biological Evaluation of Hybrid-typeC3-Symmetrical Alkoxy Benzylamino-Substituted 1,3,5-Triazine Derivatives
○Yumemi Matsumoto1, Nobuko Mibu1, Kenyu Syu2, Kazumi Yokomizo2, Makoto Furutachi1, Kunihiro Sumoto1 (1. Fukuoka University, 2. Sojo University)
[27P-am037]Synthesis of Ester Containing Symmetric Boronic Acid Derivatives
○Riko Sugimachi1, Kaori Ota1, Makoto Furutachi1 (1. Fukuoka University)
[27P-am038]The Influence of Electron Donating and Withdrawing Substituents to Biological Activity of Symmetric Boronic Acid Derivatives
○Tashiro Tomoko1, Kaori Ota1, Jian-Rong Zhou2, Kazumi Yokomizo2, Nobuhiro Kashige1, Makoto Furutachi1 (1. Fukuoka University, 2. Sojo University)
[27P-am039]Synthesis of Non-symmetric Boronic Acid Derivatives
○Nao Rikimaru1, Kaori Ota1, Makoto Furutachi1 (1. Fukuoka University)
[27P-am040]Synthesis and spectra of 2-(4-dimethylaminophenyl)benzothiazole derivatives possessing boron substituents at 5- or 6-position
○Shinobu Honzawa1, Takumichi Sugihara1 (1. Fac. Pharm. Sci., NUPALS)
[27P-am041]Development of trimethoxyphenyl derivatives having m-carborane cage as novel anti-cancer agents
○Asako Kaise1, Kiminori Ohta2, Yasuyuki Endo1 (1. Fac. Pharm. Sci. Tohoku Med. Pharm. Univ., 2. Sch. Pharm. Showa Univ.)
[27P-am042S]Development of boron carriers for boron neutron capture therapy targeting tumor highly-expressed transporter
○Akari Matsushita1, Mieko Tsuji1, Tasuku Hirayama1, Hideko Nagasawa1 (1. Gifu Pharm. Univ.)
[27P-am043]Synthesis benzofuro[3,2-c]pyridines as 5-HT2C agonist
○Yuki Ichikawa1, Takashi Nishiyama2, Shinichi Suzuki1, Satoshi Hibino2, Tominari Choshi2, Noriyuki Hatae1 (1. Fac. Pharma. Sci., Yokohama Univ. Pharm., 2. Fac. Pharma. Sci. & Grad. Sch. Pharm. Sci., Fukuyama Univ.)