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Tue. Mar 10, 2026

Wed. Mar 11, 2026

Thu. Mar 12, 2026

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Neural mechanisms for persistent goal pursuit: role of prediction updating in the hippocampus and nucleus accumbens

Co-hosted by: KAKENHI Transformative Research Areas (A) "Adaptive Circuit Census"

This symposium highlights emerging research that revises traditional views on the brain's predictive mechanisms essential for survival. The hippocampus, known for episodic memory-based prediction and replay, produces sharp-wave ripples. The basal ganglia support reinforcement learning via dopamine-based reward prediction errors. Tsutsui-Kimura expands basal ganglia prediction mechanisms beyond reward. Ogawa reveals dual-polarity of prediction errors in the basal ganglia and explores hippocampal roles. Rios revisits the functional significance of hippocampal ripples in relation to the reward system. Yanagisawa links hippocampal ripples to spontaneous thoughts using human intracranial EEG. The symposium will share these advances and deepen our understanding of neural prediction mechanisms.

The 103rd Annual Meeting of The Physiological Society of Japan

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[1S07e-02]Neural mechanisms for persistent goal pursuit: role of prediction updating in the hippocampus and nucleus accumbens

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