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Tue. Mar 10, 2026

Wed. Mar 11, 2026

Thu. Mar 12, 2026

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Blood flow sensing in vascular endothelial cells and circulatory regulation

A central question in cardiovascular research is why atherosclerotic and aneurysmal lesions preferentially develop at arterial regions exposed to disturbed rather than laminar blood flow.<br>In this seminar, recent findings obtained using in vitro flow-loading and disturbed-flow systems that reproduce defined hemodynamic environments (and enable live imaging of plasma membrane and mitochondrial responses in endothelial cells) will be presented.<br>The seminar will also discuss how these hemodynamic platforms can be refined for disease modeling and drug discovery, and what this implies for future device development and integration with automated systems.

【J】Blood flow and endothelial mechanosensing: in vitro platforms reproducing hemodynamic environments and their implications for device development

The 103rd Annual Meeting of The Physiological Society of Japan

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[2LS07-02]Blood flow sensing in vascular endothelial cells and circulatory regulation

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