Session Details
[2LS07]【J】Blood flow and endothelial mechanosensing: in vitro platforms reproducing hemodynamic environments and their implications for device development
Wed. Mar 11, 2026 12:10 PM - 1:00 PM JST
Wed. Mar 11, 2026 3:10 AM - 4:00 AM UTC
Wed. Mar 11, 2026 3:10 AM - 4:00 AM UTC
Room 7(School of Nursing Building, 1F, 102)
Chairperson:Shigetomo Fukuhara (Dept. of Mol. Pathophysiol., Inst. of Adv. Med. Sci., Nippon Medical School)
Co-sponsored:KOGANEI Corporation
A central question in cardiovascular research is why atherosclerotic and aneurysmal lesions preferentially develop at arterial regions exposed to disturbed rather than laminar blood flow.
In this seminar, recent findings obtained using in vitro flow-loading and disturbed-flow systems that reproduce defined hemodynamic environments (and enable live imaging of plasma membrane and mitochondrial responses in endothelial cells) will be presented.
The seminar will also discuss how these hemodynamic platforms can be refined for disease modeling and drug discovery, and what this implies for future device development and integration with automated systems.
In this seminar, recent findings obtained using in vitro flow-loading and disturbed-flow systems that reproduce defined hemodynamic environments (and enable live imaging of plasma membrane and mitochondrial responses in endothelial cells) will be presented.
The seminar will also discuss how these hemodynamic platforms can be refined for disease modeling and drug discovery, and what this implies for future device development and integration with automated systems.
[2LS07-02]Blood flow sensing in vascular endothelial cells and circulatory regulation
*Kimiko Yamamoto (System Physiology, Department of Biomedical Engineering,Graduate School of Medicine,The University of Tokyo)