The 103rd Annual Meeting of The Physiological Society of Japan
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Session Details

SymposiumInternational Relations Committee Symposium

[1S07a]Molecular Pathophysiology of Cellular Senescence and Aging

Tue. Mar 10, 2026 2:30 PM - 4:20 PM JST
Tue. Mar 10, 2026 5:30 AM - 7:20 AM UTC
Room 7(School of Nursing Building, 1F, 102)
Organizer: Naoko Ohtani (Osaka Metropolitan University)
Chairs: Naoko Ohtani (Osaka Metropolitan University), Shimpei Kawamoto (Tohoku University)
Co-hosted by: JSPS A3 Foresight Program "The mechanism of cellular senescence in aging and chronic diseases: exploration of senescence biomarkers and target molecules for therapeutic potential"
Understanding organismal aging requires integrated insights into age-related physiological changes at molecular, cellular, and systemic levels across organs. While cellular senescence contributes to aging, its impact varies by biological context. In this international symposium, researchers from KRIBB, Korea, will join Japanese specialists to explore mechanisms of aging. Under the theme “Molecular Pathophysiology of Cellular Senescence and Aging", topics include oocyte aging, single-cell changes in aged organs, shifts in gut microbiota and intestinal immunity, senescence in the tumor microenvironment, and anti-aging effects of exercise.
2:30 PM - 2:31 PM JST(5:30 AM - 5:31 AM UTC)

Introduction

2:31 PM - 2:49 PM JST(5:31 AM - 5:49 AM UTC)

[1S07a-01]Aging induces heritable epigenetic changes in oocytes

Fukushima Hiroto1, Chisayo Kozuka1, Akiko Oguchi1, Mami Kumon1, Yasuhiro Murakawa1, *Azusa Inoue1 (1. RIKEN IMS)
Comment()
2:49 PM - 2:53 PM JST(5:49 AM - 5:53 AM UTC)

Q&A

2:53 PM - 3:11 PM JST(5:53 AM - 6:11 AM UTC)

[1S07a-02]Age-related disruption of the crosstalk between host and commensal microbiota through cellular senescence

*Shimpei Kawamoto1 (1. Institute of Development, Aging and Cancer, Tohoku University)
Comment()
3:11 PM - 3:15 PM JST(6:11 AM - 6:15 AM UTC)

Q&A

3:15 PM - 3:33 PM JST(6:15 AM - 6:33 AM UTC)

[1S07a-03]Quasi-spatial single-cell transcriptome based on physical tissue properties defines early aging associated niche in liver

*Chuna Kim1,2 (1. Korea Research Institute of Bioscience and Biotechnology (KRIBB), 2. University of Science and Technology (UST))
Comment()
3:33 PM - 3:37 PM JST(6:33 AM - 6:37 AM UTC)

Q&A

3:37 PM - 3:55 PM JST(6:37 AM - 6:55 AM UTC)

[1S07a-04]Exercise-induced CLCF1 attenuates agerelated
muscle and bone decline in mice

*Yong Ryoul Yang1,2, Jung Ha Kim3, Min Ju Kim1,2, Nacksung Kim3, Ki-Sun Kwon4 (1. Korea Research Institute of Bioscience and Biotechnology (KRIBB), 2. University of Science and Technology (UST), 3. Chonnam National University Medical School, 4. Aventi Inc.)
Comment()
3:55 PM - 3:59 PM JST(6:55 AM - 6:59 AM UTC)

Q&A

3:59 PM - 4:16 PM JST(6:59 AM - 7:16 AM UTC)

[1S07a-05]Mechanism of Tissue Homeostasis Perturbation in Cancer and Aging

*Naoko Ohtani1 (1. Osaka Metropolitan University, Graduate School of Medicine)
Comment()
4:16 PM - 4:20 PM JST(7:16 AM - 7:20 AM UTC)

Q&A

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