Presentation Information
[P-17]Neonatal systemic AAV9 administration is associated with genome-dependent cardiac inflammation and fibrosis in mice
*Hiroshi Ueki1,2, Yuji Tsunekawa3, Mikako Wada3, Ken Sugo3, Azusa Onodera3, Kiyoko Iwatsuki-Horimoto1,6, Hiromi Hayashita-Kinoh3, Yuri Furusawa1,6, Yoshihiro Kawaoka1,2,4,6,5, Seiya Yamayoshi1,2,5,6, Takashi Okada3 (1. Department of Virology, The UTOPIA Center, The University of Tokyo (Japan), 2. The Research Center for Global Viral Diseases, National Institute of Global Health and Medicine, Japan Institute for Health Security (Japan), 3. Division of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo (Japan), 4. Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison (USA), 5. Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo (Japan), 6. Division of Virology, Institute of Medical Science, University of Tokyo (Japan))
Keywords:
AAV vector,AAV9,Gene therapy,mouse model,cardiac fibrosis
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