[WS(P)17] B cell activation and differentiation

[WS17-09-P] Newly Identified Gain-of-Function Mutation in BTK SH3 domain Promotes B-1 B Cell Expansion and Autoantibody Production

^○Xin Meng¹, Wenjie Wang², Hai Zhang², Lulu Dong³, Xin Lan⁴, Qing Min⁵, Jingjing Zhao¹, Meiping Yu², Lipin Liu², Xiaochuan Wang^2,6, Ji-Yang Wang^3,2,5 (1.Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China, 2.Department of Clinical Immunology, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, China, 3.Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China, 4.Department of Infectious Diseases,Jiangxi Provincial Children's Hospital/Children's Hospital Affiliated to Nanchang Medical College, Jiangxi, China, 5.Shanghai Sci-Tech Inno Center for Infection & Immunity, Shanghai, China, 6.Shanghai Institute of Infectious Disease and Biosecurity, Shanghai, China)

キーワード：

B cell、autoimmune、autoantibody、BTK、B-1

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