セッション詳細
[WS(P)17]B cell activation and differentiation
2024年12月4日(水) 16:40 〜 17:25
Poster 2
[WS17-01-O/P]Role of antigen and IgM persistent in endosome/lysosome in T cell-independent antibody response to polysaccharides
○Asahi Nunokawa1,2, Kana Matsumura1, Huang Yuming1, Takeshi Tsubata1,2 (1.Tokyo Medical and Dental University, 2.Nihon University School of Dentistry)
[WS17-02-O/P]Essential roles of FcμR and complement activation in eliciting effective humoral immunity
○Zichao Wen1, Lulu Dong1, Jun Liu1, Qing Min2, Ying Wang1, Ziying Hu3, Xiaoqian Feng1, Chaoqun Cui1, Yingying Luan1, Yaxuan Li1, Birgitta Heyman5, Ji-Yang Wang1,2,4 (1.Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China., 2.Shanghai Sci-Tech Inno Center for Infection & Immunity, Shanghai, China., 3.Department of Microbiology and Immunology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China., 4.Department of Clinical Immunology, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, China., 5.Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.)
[WS17-04-O/P]Explore the alteration of B cell caused by Bach2-deficiency
○Kyoko Ochiai1, Yayoi Kimura2, Kazuhiko Igarashi1 (1.Biochemistry, Tohoku University Graduate School of Medicine, 2.Advanced Medical Research Center, Yokohama City University)
[WS17-03-O/P]The contribution of IL-9 receptors on peritoneal B cells and ILC2 to the T-cell-independent immune responses
○Mari Tenno, Takumi Umezu, Yuko Emoto, Haruna Sato, Kei Kato, Daisuke Kitamura (Toyko University of Science)
[WS17-05-O/P]Plasma cell KLF2 expression at the induction site directs migration to the bone marrow
Wataru Ise1,2,8, ○Takuya Koike1,2,7,8, Yuki Tai2, Taiichiro Shirai3, Ryoji Kawakami4, Takeshi Inoue2, Nozomi Hojo5, Katsuyuki Shiroguchi5, Kazuhiro Suzuki3, Tomohiro Kurosaki2,6,7 (1.Regulation of Host Defense Team, Division of Microbiology and Immunology, Center for Infectious Disease Education and Research, Osaka University, 2.Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, 3.Laboratory of Immune Regulation, WPI Immunology Frontier Research Center, Osaka University, 4.Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, 5.Laboratory for Prediction of Cell Systems Dynamics, RIKEN Center for Biosystems Dynamics Research (BDR), 6.Center for Infectious Diseases Education and Research, Osaka University, 7.Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS), 8.These authors contributed equally)
[WS17-06-O/P]Autoreactive B cells are formed by somatic hypermutation without help of autoreactive T cells
○Wataru Okada, Shun Tokumoto, Sano Nagano, Miya Yoshino, Koji Tokoyoda (Division of Immunology, School of Life Science, Faculty of Medicine, Tottori University)
[WS17-07-O/P]Humanized BCR mice are a useful tool for analysis of autoreactive B cells
○Rinka Ito1, Yutaro Yada1, Yasuhiro Kazuki2, Yoshihiro Baba1 (1.Medical Institute of Bioregulation, Kyushu Univ., 2.Tottori Univ.)
[WS17-08-O/P]All-trans-retinoic acid suppresses age-associated B cell generation and ameliorates autoimmunity
○keisuke imabayashi, Yoshihiro Baba (Division of Immunology and Genome Biology, Medical Institute of Bioregulation, Kyushu University)
[WS17-09-P]Newly Identified Gain-of-Function Mutation in BTK SH3 domain Promotes B-1 B Cell Expansion and Autoantibody Production
○Xin Meng1, Wenjie Wang2, Hai Zhang2, Lulu Dong3, Xin Lan4, Qing Min5, Jingjing Zhao1, Meiping Yu2, Lipin Liu2, Xiaochuan Wang2,6, Ji-Yang Wang3,2,5 (1.Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China, 2.Department of Clinical Immunology, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, China, 3.Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China, 4.Department of Infectious Diseases,Jiangxi Provincial Children's Hospital/Children's Hospital Affiliated to Nanchang Medical College, Jiangxi, China, 5.Shanghai Sci-Tech Inno Center for Infection & Immunity, Shanghai, China, 6.Shanghai Institute of Infectious Disease and Biosecurity, Shanghai, China)
[WS17-10-P]Protein kinase D is essential for B cell activation and humoral immunity
○Airi Shibata1, Keisuke Imabayashi1, Eri Ishikawa2, Tomoharu Yasuda3, Sho Yamasaki2, Yoshihiro Baba1 (1.Department of Immunology and Genome Biology, Medical Institute of Bioregulation, Kyushu University, 2.Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3.Department of Immunology, Hiroshima University)
[WS17-11-P]The roles of Cyclin-Dependent Kinase 9 in B activation
○Shin-ichi Tsukumo, Koji Yasutomo (Tokushima University)
[WS17-12-P]Regulatory mechanisms of class-switch recombination of immunoglobulins via cis-regulatory elements for Aicda gene expression.
○Merumo Shimizu1, Kazuko Miyazaki1, Daisuke Kitamura2, Hiroshi Kawamoto1, Masaki Miyazaki1 (1.Institute for life and medical sciences, Kyoto University, 2.Tokyo University of Sciences)
[WS17-13-P]B cell-intrinsic Arf1 plays a pivotal role in germinal center formation.
○Yui Kotani1,2, Mami Sumiyoshi1, Madoka Ozawa3, Tomoya Katakai3, Satoshi Matsuda1 (1.Dept. Cell signaling, Ins. of Biomed. Sci., Kansai Medical Univ., 2.Department of Vascular Physiology, National Cerebral and Cardiovascular Center, Research Institute, 3.Dept. Immunol., Niigata Univ. Grad. Sch. of Med. and Dent. Sci.)
[WS17-14-P]HuR/ELAVL1 is essential for the activation-induced cytidine deaminase- dependent decrease of Topoisomerase 1 in antibody diversification
○WAJID AMIN (KYOTO UNIVERSITY)
[WS17-15-P]Pulmonary administration of a nonreplicating adenoviral vector vaccine generates more potent and broader neutralizing IgGs against SARS-CoV-2 spike than intramuscular administration
○Toshiro Hirai1,2, Koki Ueda2, Mako Kakihara2, Kazuo Takayama3, Yasuo Yoshioka1,2,4,5 (1.OTRI/CAMaD, Osaka Univ., 2.Pharm Sci/RIMD, Osaka Univ., 3.CiRA, Kyoto Univ., 4.CiDER/MEI, Osaka Univ., 5.BIKEN Foundation)
[WS17-16-P]Ca2+/calmodulin-dependent protein kinase II is involved in the regulation of IgE class switch recombination, but not the differentiation in human B cells
○Kano Tanabe, Yukinori Kozuma (Faculty of Health Science, Kumamoto Health Science University)
[WS17-17-P]The critical role of H3K27me3 enzyme subunit Eed in the early phase of germinal center formation
○Man Zhang, Yun Guo, Tomoharu Yasuda (Department of Immunology, Hiroshima University)
[WS17-18-P]A mutation type of activation-induced cytidine deaminase reveals novel functional regulation of class switch recombination
○Yuchen Zhang1,2, Peng Gao1, Naoki Morita1, Ayako Isotani3, Shunsuke Yuri3, Reiko Shinkura1,2 (1.Institute of Quantitative Biosciences, The University of Tokyo, 2.Graduate School of Frontier Sciences, The University of Tokyo, 3.Nara Institute of Science and Technology)
[WS17-19-P]Regulation of humoral immunity by differential use of BACH1 and BACH2
○Takeshi Kurasawa1, Akihiko Muto1, Mitsuyo Matsumoto2, Kyoko Ochiai1, Ari Itoh3, Kazutaka Murayama4, Kazuhiko Igarashi1,5 (1.Dept. Biochem., Tohoku Univ. Grad. Sch. Med., 2.Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 3.Dept. Hygiene and Public health., Nippon Medical School. Grad. Sch. Med, 4.Dept. Biomedical Supramolecular Analysis., Tohoku Univ. Grad. Sch. Biomedical engineering, 5.Ctr. Regulatory Epigenome&Disease, Tohoku Univ. Grad. Sch. Med.)
[WS17-20-P]STAP-1 acts as a scaffold protein for positive regulation of CD40 signals in B cells
○Shoya Kawahara1, Jun-ichi Kashiwakura2, Kenji Oritani3, Tadashi Matsuda1 (1.Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Hokkaido, Japan, 2.Department of Life Science, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, Hokkaido, Japan, 3.Department of Hematology, International University of Health and Welfare, Tochigi, Japan)