講演情報
[WS25-13-P]Hu-PBL-NOG-hIL-4-Tg mouse system maintains human adoptive immunity to produce antigen-specific plasmablasts.
○Shino Ohshima1, Soga Yamada1, Ayako Hirota2, Nagi Katano1, Banri Tsuda3, Atsushi Yasuda4, Yukio Nakamura5, Ryoji Ito6, Tomotaka Mabuchi2, Hitoshi Ishimoto7, Takashi Shiina1,8, Yoshie Kametani1,8 (1.Department of Molecular Life Science, Division of Basic Medical Science, Tokai University School of Medicine, 2.Department of Dermatology, Tokai University School of Medicine, 3.Department of Palliative Medicine, Tokai University School of Medicine, 4.Department of Internal Medicine, Division of Nephrology, Endocrinology, and Metabolism, Tokai University School of Medicine, 5.Repertoire Genesis Inc., 6.Human Disease Model Laboratory, Department of Applied Research for Laboratory Animals, Central Institute for Experimental Animals, 7.Department of Obstetrics and Gynecology, Tokai University School of Medicine, 8.Institute of Advanced Biosciences, Tokai University)
キーワード：
humanized mouse、PBMC、repertoire analysis、specific antibody、class switch、affinity maturation
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