セッション詳細

[WS(P)25]B cell homeostasis

2024年12月5日(木) 15:00 〜 15:45
Poster 3

[WS25-01-O/P]The trinity of transcription factors E2A, Ebf1 and Erg guides lymphoid progenitors to B cell lineage.

Rinako Hayashi1, Reiko Hidaka1, Kazuko Miyazaki1, Takashi Nagasawa2, Hiroshi Kawamoto1, Masaki Miyazaki1 (1.Institute for Life and Medical Sciences, Kyoto University, 2.Graduate School of Frontier Biosciences, Osaka University)

[WS25-02-O/P]Critical roles of UPF1 in early B cell development

Kotaro Akaki, Noriki Iwai, Takashi Mino, Osamu Takeuchi (Department of Medical Chemistry, Graduate School of Medicine, Kyoto University)

[WS25-03-O/P]Self-enforcing networks of inflammatory cytokine signaling accelerate the development and recurrence of TCF3::HLF-positive B-ALL.

Aisa Suzuki, Tsukasa Shigehiro, Tomokatsu Ikawa (Research Institutes for Biomedical Sciences ,Tokyo University of Science)

[WS25-04-O/P]Essential role of ER membrane complex subunit 1 (EMC1) in B cell homing and humoral immunity

Kazuhiko Kawata1, Chie Kikutake2, Mikita Suyama2, Yoshihiro Baba1 (1.Division of Immunology and Genome Biology, Medical Institute of Bioregulation, Kyushu University, 2.Medical Institute of Bioregulation, Bioinformatics, Kyushu University, Japan)

[WS25-05-O/P]Control of IgE production and germinal center B cell survival by Aps/Sh2b2, a member of Lnk-family adaptor proteins.

Shinya Hidano1, Masanori Iseki2, Satoshi Takaki1 (1.Department of Immune Regulation, The Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine., 2.Department of Immunology and Molecular Genetics, Kawasaki Medical School.)

[WS25-06-O/P]The J chain acts as a critical regulator for intestinal IgA+ plasma cell differentiation before weaning

Ryo Goitsuka1, Keiko Fujisaki2 (1.Research Institute for Biomedical Sciences, Tokyo University of Science, 2.Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences)

[WS25-07-O/P]Atypical and non-classical CD45RBlo memory B cells are the majority of circulating SARS-CoV-2 specific B cells following mRNA vaccination or COVID-19

David Geoffrey Priest1, Takeshi Ebihara2,3, Janyerkye Tulyeu4, Jonas N. Søndergaard4, Yumi Mitsuyama3, Hisatake Matsumoto2,3, James B. Wing1,4,5 (1.Laboratory of Human Single Cell Immunology, World Premier International Research Center Initiative Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Osaka 563-0793, Japan, 2.Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Osaka 565-0871, Japan., 3.Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan., 4.Human Single Cell Immunology Team, Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Osaka 565-0871, Japan., 5.Center for Advanced Modalities and DDS (CAMaD), Osaka University, Osaka, Japan.)

[WS25-08-O/P]The COMMD3/8 complex drives plasmablast differentiation of age-associated B cells during extrafollicular responses in lupus

Taiichiro Shirai1,2, Kentaro Kuzuya1, Kazuhiro Suzuki1,2,3 (1.Laboratory of Immune Response Dynamics, Immunology Frontier Research Center, Osaka University, Japan, 2.Department of Immune Response Dynamics, Research Institute for Microbial Diseases, Osaka University, Japan, 3.Center for Infectious Disease Education and Research, Osaka University, Japan)

[WS25-09-P]IgA-deficiency breaks immunological and neurological homeostasis

Takahiro Adachi (Dept. Precision Health, MRI, TMDU)

[WS25-10-P]Disruption of plasma cell differentiation through complex interplay of loss, gain, and altered IRF4 functions

Qing Min1, Yaxuan Li2, Wenjie Wang3, Xin Meng4, Hai Zhang3, Meiping Yu3, Lulu Dong2, Xuzhe Wu2, Xiaochuan Wang3, Ji-Yang Wang1,2,3 (1.Shanghai Sci-Tech Inno Center for Infection & Immunity, Shanghai, China., 2.Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China., 3.Department of Clinical Immunology, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, China., 4.Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China)

[WS25-11-P]Function and role of complexin 2-expressing B-1 cells in immune tolerance

Emi Tsuru1, Hiroki Mogawa2, Atsuya Nobumoto2, Masaaki Mizobuchi2, Masayuki Tsuda1 (1.Institute for Laboratory Animal Research, Science Research Center, Kochi University, 2.Equipment Support Planning Office, Kochi University)

[WS25-12-P]Human RP105 monoclonal antibody promotes antigen-specific antibody production under unique culture conditions

Tatsuya Yamazaki1, Kenta Iwasaki2, Susumu Tomono1, Masaki Imai3, Masanori Inui1, Daisuke Okuzaki4, Sachiko Akashi-Takamura1 (1.Department of Microbiology and Immunology, Aichi Medical University School of Medicine, 2.Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, 3.Department of Medical Technology and Sciences, Kyoto Tachibana University, 4.Laboratory of Human Immunology (Single Cell Genomics), WPI-IFReC, Osaka University)

[WS25-13-P]Hu-PBL-NOG-hIL-4-Tg mouse system maintains human adoptive immunity to produce antigen-specific plasmablasts.

Shino Ohshima1, Soga Yamada1, Ayako Hirota2, Nagi Katano1, Banri Tsuda3, Atsushi Yasuda4, Yukio Nakamura5, Ryoji Ito6, Tomotaka Mabuchi2, Hitoshi Ishimoto7, Takashi Shiina1,8, Yoshie Kametani1,8 (1.Department of Molecular Life Science, Division of Basic Medical Science, Tokai University School of Medicine, 2.Department of Dermatology, Tokai University School of Medicine, 3.Department of Palliative Medicine, Tokai University School of Medicine, 4.Department of Internal Medicine, Division of Nephrology, Endocrinology, and Metabolism, Tokai University School of Medicine, 5.Repertoire Genesis Inc., 6.Human Disease Model Laboratory, Department of Applied Research for Laboratory Animals, Central Institute for Experimental Animals, 7.Department of Obstetrics and Gynecology, Tokai University School of Medicine, 8.Institute of Advanced Biosciences, Tokai University)

[WS25-14-P]The dynamics of iron metabolism during antibody secreting cell differentiation

Akihiko Muto, Takeshi Kurasawa, Kazuhiko Igarashi (Department of Biochemistry, Tohoku University Graduate School of Medicine)

[WS25-15-P]Reversal of brain dysfunction through control of senescent cells

Ayame Nagafuchi1, Mana Iizuka2, Ako Matsui1, Akihiko Yoshimura2, Minako Ito1 (1.Division of Allergy and Immunology, Medical Institute of Bioregulation, Kyushu University, 2.Research Institute for Biomedical Sciences, Tokyo University of Science)

[WS25-16-P]Bone marrow plasma cells express metallothionein genes in response to IL-6 stimulation

Ari Itoh-Nakadai1, Masayuki Shirota3, Atsuko Kayaba3, Akiko Sugahara-Tobinai3, Maiko Kobayashi1, Shota Endo3, Masanori Inui2, Tomoyuki Kawada1, Ryo Funayama3, Keiko Nakayama3, Toshiyuki Takai3 (1.Nippon Medical School, 2.Aichi Medical Univ., 3.Tohoku Univ.)

[WS25-17-P]Analyses on the roles of extracellular domain of Parm1

Runa Isshiki1, Kagefumi Todo2, Haruka Honda1, Masaki Hikida1 (1.Graduate School of Engineering Science, Akita University, 2.Department of Health and Nutrition, Tokiwa University)

[WS25-18-P]Analysis on the regulatory mechanism of selective transcription of Parm1 in IgG+ B cells.

Shiori Hatakeyama1, Kagefumi Todo2, Haruka Honda1, Masaki Hikida1 (1.Graduate School of Engineering Science, Akita University, 2.Department of Health and Nutrition, Tokiwa University)

[WS25-19-P]Evaluation of the IRF4 heterocomplexes and homodimers induced by mutations in the IRF association domain and autoinhibitory region

Katsuya Sato1, Yupeng Li1, Setoka Hirano1, Masatake Osawa2, Hitoshi Nagaoka1 (1.Department of Molecular Pathobiochemistry, Gifu University School of Medicine, 2.Department of Regeneration and Applied Biomedical Sciences, Gifu University School of Medicine)

[WS25-20-P]Variable gene repertoire analysis of antibodies against SARS-CoV-2 spike protein

Makoto Tsuiji, Sayaka Mori, Hinako Ohkusa, Shinichi Fujihara (Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences)