セッション詳細
[WS(P)20]Organ-Specific Immune Diseases
2024年12月4日(水) 16:40 〜 17:25
Poster 5
[WS20-01-O/P]Neutrophil-derived IL-23 p19 monomer suppresses type 17 immunity
○Daiya Ohara, Yusuke Takeuchi, Yoonha Lee, Hiroki Mukoyama, Hitomi Watanabe, Gen Kondoh, Keiji Hirota (Institute for Life And Medical Sciences, Kyoto University)
[WS20-02-O/P]Th1-type Tregs induced by interferon-γ limit EAE exacerbation
○Masaaki Okamoto1, Naganori Kamiyama4, Takashi Kobayashi4,5, Masahiro Yamamoto1,2,3 (1.Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, 2.Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University, 3.Department of Immunoparasitology, Center for Infectious Disease Education and Research, Osaka University, 4.Department of Infectious Disease Control, Faculty of Medicine, Oita University, 5.Research Center for GLOBAL and LOCAL Infectious Diseases, Oita University)
[WS20-03-O/P]Stage-dependent dynamics of resident memory T cells in lesion sites of multiple sclerosis and neuromyelitis optica spectrum disorders
○Fumihiro Yanagimura1,5, Akihiro Nakajima1, Etsuji Saji1, Takashi Nakajima5, Hiroshi Shimizu2, Yasuko Toyoshima2,7, Hitoshi Takahashi6,8, Akiyoshi Kakita2, Masatoyo Nishizawa4,8, Osamu Onodera1, Izumi Kawachi1,3 (1.Department of Neurology, Brain Research Institute, Niigata University, 2.Department of Pathology, Brain Research Institute, Niigata University, 3.Medical Education Center, Niigata University School of Medicine, 4.Niigata University of Health and Welfare, 5.Department of Neurology, NHO Niigata National Hospital, 6.Niigata Neurosurgical Hospital, 7.Agano Hospital, 8.Brain Research Institute, Niigata University)
[WS20-04-O/P]Ketogenic diet regulates autoimmune neuroinflammation via changes in small intestinal gut microbiome.
○Katsuki Yaguchi1,2, Tadashi Takeuchi1,3, Eiji Miyauchi1,4, Masami Kawasumi1, Yumiko Nakanishi1, Tamotsu Kato1, Jigen Sekine1, Shin Maeda2, Hiroshi Ohno1,5 (1.Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., 2.Department of Gastroenterology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan., 3.Department of Microbiology and Immunology, Stanford University School of Medicine, California, USA., 4.Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan., 5.Immunobiology Laboratory, Department of Medical Life Science, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.)
[WS20-05-O/P]Akkermansia muciniphila endorses T cell pathogenicity and invasion to CNS in experimental autoimmune encephalomyelitis
○Manu Mallahalli Shanthappa1, Hirohiko Hohjoh2, Daiki Takewaki1, Shinji Oki1, Wakiro Sato1, Takashi Yamamura1 (1.Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashicho, Kodaira, Tokyo ., 2.Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashicho, Kodaira, Tokyo)
[WS20-06-P]An Engineered Probiotic Produces a Type III Interferon IFNL1 and Reduces Inflammations in in vitro Inflammatory Bowel Disease Models
○Koon Jiew Eri Chua1,2,3,4, Hua Ling1,2,3,4, In Young Hwang1,2,3,4, Hui Ling Lee1,2,3,4, John C March5, Yung Seng Lee1,2,6, Matthew Wook Chang1,2,3,4 (1.National University of Singapore, NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Singapore, Singapore, 2.National University of Singapore, Synthetic Biology Translational Research Programme, Singapore, Singapore, 3.National University of Singapore, Department of Biochemistry, Singapore, Singapore, 4.National University of Singapore, Wilmar-NUS Corporate Laboratory, Singapore, Singapore, 5.Cornell University, Department of Biological and Environmental Engineering, Ithaca, NY, 6.National University of Singapore, Department of Paediatrics, Singapore, Singapore)
[WS20-07-P]Treatment of multiple sclerosis by immunomodulatory glycolipid OCH in Phase II Clinical Trial and in an animal model
○Atsuko Kimura1, Ben JE Raveney1, Tomoko Okamoto2, Wakiro Sato1, Shinji Oki1, Youwei Lin2, Sachiko Miyake3, Yuji Takahashi2, Takashi Yamamura1 (1.Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), 2.Department of Neurology, National Center Hospital, NCNP, 3.Department of Immunology, Juntendo University Graduate School of Medicine)
[WS20-08-P]Investigation of anti-inflammatory effects of nicotine in ulcerative colitis (UC) using a PET imaging agent, [18F]ASEM
○Kohei Nakajima, Genki Yoshino, Mikako Ogawa (Graduate School of Pharmaceutical Sciences, Hokkaido Univ.)
[WS20-09-P]Phenotypic Validation of Humanized IgA1 and CD89 Transgenic Mice as a Model for IgA Nephropathy-Like Autoimmune Disease
○Kaiyuan Zi, Juan Liang (GemPharmatech Co., Ltd.)
[WS20-10-O/P]CXCL13 producing peripheral helper T cell (Tph) is a crucial pathogenesis in Castleman disease (iMCD)
○Kazuyuki Yoshizaki1, Yoshikane Kikushige2, Takuya Harada2, Hiroaki Niiro2, Kazuko Uno3, Atsushi Kawakami4, Tomohiro Koga4 (1.Osaka Univ., 2.Kyushu Univ., 3.Louis Pasteur Center for Medical Research, 4.Nagasaki -Univ.)
[WS20-11-P]Gut Dysbiosis with AHR Activation Exacerbates the Pathogenesis of Pulmonary Arterial Hypertension
○Ryotaro Asano, Makoto Okazawa, Tadakatsu Inagaki, Yui Kotani, Xin Ding, Tomohiko Ishibashi, Takeshi Ogo, Yoshikazu Nakaoka (National Cerebral and Cardiovascular Center)
[WS20-12-O/P]Identification of PTPN2 as a population-specific susceptibility locus for primary biliary cholangitis through genome-wide association study
○Yuki Hitomi1, Yoshihiro Aiba2, Kazuyoshi Ishigaki3, Minoru Nakamura2,4,5 (1.Department of Human Genetics, Research Institute, National Center for Global Health and Medicine, 2.Clinical Research Center, NHO Nagasaki Medical Center, 3.Laboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences, 4.Division of Biomedical Information Analysis, Medical Institute of Bioregulation, Kyushu University, 5.Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences)
[WS20-13-P]Hepatic stellate cells in primary biliary cholangitis display an increase of molecules associated with antigen-presentation capacities
○Toshiaki Bando1, Hajime Morita1, Lynn Zreka1, Shuhe Ma1,3, Mouna Khan1, Daichi Akuzawa1, Yuki Masuo1, Shunsuke Uno1, Hirotaka Sato1, Takashi Ito2, Hideki Ueno1,3,4 (1.Department of Immunology Graduate School of Medicine, Kyoto University, 2.Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, 3.ASHBi Institute for the Advanced Study of Human Biology, Kyoto University, 4.Kyoto University Immunomonitoring Center (KIC), Kyoto University)
[WS20-14-P]AI-Driven Epigenetic Analysis Reveals Novel Therapeutic Targets in Primary Sclerosing Cholangitis
○Elfiany Syafruddin1, Prihantini Prihantini2, Andi Nursanti Ureng3, Rifaldy Fajar4, Sahnaz Vivinda Putri5, Roland Helmizar6 (1.Computational Research Team, Bulukumba Muhammadiyah University, Indonesia, 2.Machine Learning for BioMedicine Laboratory, Bandung Institute of Technology, Indonesia, 3.Department of Pharmacy, Andini Persada College of Health Sciences, Indonesia, 4.Computational Biology and Medicine Laboratory, Yogyakarta State University, Indonesia, 5.Health Management Laboratory, International University Semen Indonesia, Indonesia, 6.Department of Internal Medicine, Baiturrahmah University, Indonesia)
[WS20-15-O/P]Development of novel therapy targeting gut microbiota for primary sclerosing cholangitis.
○Haruka Okada1, Masataka Ichikawa2, Nobuhiro Nakamoto1, Takanori Kanai1 (1.Division of Gastroenterology & Hepatology, Department of Internal Medicine, Keio University School of Medicine, 2.Division of Gastroenterology, TOkyo Dental College Ichikawa General Hospital)
[WS20-16-P]Butyrate-regulated Histone Modifications in Orbital Fibroblast from Graves’ Ophthalmopathy
○Sukonlaphat Pitikeattikul1, Preamjit Saonanon2, Vannakorn Pruksakorn2, Tanapat Palaga3, Sita Virakul3 (1.Medical Microbiology, Interdisciplinary Program, Graduate School, Chulalongkorn University, Bangkok, Thailand, 2.Department of Ophthalmopathy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, 3.Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand)
[WS20-17-P]IgM-type anti-TSH receptor antibody produced through gene transfection
○Keiko Nagata1, Shusei Hamamichi2, Yoshinori Ichihara1, Tatsuya Sawano1, Kanako Kazuki2, Takashi Moriwaki2, Junichiro Miake1, Kazuhiko Matsuzawa1, Yasuhiro Kazuki2, Takeshi Imamura1 (1.Division of Pharmacology, Faculty of Medicine, Tottori University, 2.Chromosome Engineering Research Center, Tottori University)
[WS20-18-P]Vimentin knockdown attenuates PDGF-BB-induced orbital fibroblast functions in Graves’ ophthalmopathy.
○Rajit Chompoowong1, Jutamas Wongphoom2, Nakarin Kitkumthorn3, Preamjit Saonanon4, Vannakorn Pruksakorn4, Tanapat Palaga5, Nattiya Hirankarn6, Martin van Hagen6,7,8, Willem A Dik7, Sita Virakul5 (1.Medical Microbiology, Interdisciplinary Program, Graduate School, Chulalongkorn University, Bangkok, Thailand, 2.Department of Pathology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, 3.Department of Oral Biology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand, 4.Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, 5.Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand, 6.Center of Excellence in Immunology and Immune-mediated Disease, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, 7.Department of Immunology, Laboratory Medical Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands, 8.Department of Internal Medicine, Division of Clinical Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands)
[WS20-19-P]Gamma-glutamyltransferase 1 is an eQTL in nonimmune cells and is associated with the development of Post-ERCP pancreatitis via NF-κB activation
○Rie Hasebe1, Jing Jing Jiang2,3, Yuki Tanaka4, Kaoru Murakami2, Kumiko Tanaka2, Takeshi Yamasaki1, Yuta Shinohara2, Shintaro Hojyo2, Shimpei Kubota2, Shigeru Hashimoto2, Masaaki Murakami1,2,4 (1.Division of Molecular Neuroimmunology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 2.Division of Molecular Psychoneuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, 3.Institute of Preventive Genomic Medicine, School of Life Sciences, Northwest University, China, 4.Quantum Immunology Team, Institute for Quantum Life Science, National Institutes for Quantum Science and Technology)
[WS20-20-P]Pathophysiological Mechanisms of the Onset, Development, and Disappearance Phases Based on the Spatiotemporal Dynamics of Skin Eruptions in Chronic Spontaneous Urticaria
○Sungrim Seirin-Lee1, Shunsuke Takahagi2, Michihiro Hide3 (1.Kyoto University, 2.JA Hiroshima General Hospital, 3.Hiroshima City Hiroshima Citizens Hospital)
[WS20-21-P]A novel immunomodulatory compound identified through a screening targeting dendritic cell ameliorates colitis and contact hypersensitivity in mice
○Kazuki Nagata1, Fumiya Sakata1, Ayaka Sugihara1, Miki Takahashi1, Hiroyuki Hirano2, Hiroyuki Osada2,3, Chiharu Nishiyama1 (1.Department of Biological Science and Technology, Tokyo University of Science, 2.RIKEN Center for Sustainable Resource Science, 3.Institute of Microbial Chemistry (BIKAKEN))
[WS20-22-P]Pathophysiological analysis of vitiligo symptoms in autoimmune prone mice
○Yuriko Tanaka1, Marii Ise1, Taku Naito1, Taku kuwabara1, Shuhei Mashimo1,2, Akiko Inoue1,3, Motonari Kondo1 (1.Department of Molecular Immunology Toho University School of Medicine, 2.Department of Dermatology Toho University School of Medicine, 3.Department of Otolaryngology Toho University School of Medicine)
[WS20-23-P]Moesin regulates homeostasis of alveolar epithelial cells and macrophages
○Hiroki Satooka, Takako Hirata (Shiga University of Medical Science)
[WS20-24-P]Up-regulation of transcription factor ELF3 is a hallmark of human thymomas and causes a reduction of thymic regulatory T cells in mice
○Wataru Muramatsu1,2, Taishin Akiyama1,2 (1.RIKEN Center for Integrative Medical Science labratory for immune homeostasis, 2.Yokohama City Univ. Graduate School of Medical Life Science)
[WS20-25-P]Decoding Immunogenic Peptide Expression in Alzheimer's Disease via Quantum-Inspired Deep Learning on Human Leukocyte Antigen Peptidomics Data
○Sahnaz Vivinda Putri1, Prihantini Prihantini2, Andi Nursanti Ureng3, Rifaldy Fajar4, Elfiany Syafruddin5 (1.Health Management Laboratory, International University Semen Indonesia, Indonesia, 2.Machine Learning for BioMedicine Laboratory, Bandung Institute of Technology, Indonesia, 3.Department of Pharmacy, Andini Persada College of Health Sciences, Indonesia, 4.Computational Biology and Medicine Laboratory, Yogyakarta State University, Indonesia, 5.Computational Sciences Research Team, Bulukumba Muhammadiyah University, Indonesia)