講演情報
[10a-B31-5]Domain Wall Engineering: Simulating Nanoscale Electric Field Delivery to Living Cells at Ferroelectric Interfaces
〇ALEXIS BOROWIAK1,2, YOHEI KONO1,2, TAKESHI SHIMI1,2, TAKESHI FUKUMA1,2 (1.Kanazawa Univ., 2.NanoLSI)
キーワード：
Ferroelectric、Nanoendoscopy-AFM、Simulation
This work enhances the modeling of cell–ferroelectric interactions by developing a computational framework that simulates electrostatic fields at a ferroelectric-electrolyte interface. This framework couples an explicit Stern layer with a diffuse ionic layer and solves the Poisson-Boltzmann equation to account for ion crowding effects and potential profiles relevant to nanoscale membrane perturbation and electroporation. In addition, the study introduces an experimental approach to investigate living cells on Periodically Poled Lithium Niobate (PPLN), a ferroelectric crystal with opposite domains creating localized electric field gradients. Using atomic force microscopy with a nano-needle and fluorescence microscopy, HeLa cells and their nuclei were examined under these conditions. Results showed that electric fields influence cellular mechanics, reducing membrane stiffness and enabling penetration of the membrane with minimal force. Fluorescent dyes indicated increased permeability, suggesting cellular responses at opposite domain interfaces. This combined experimental and simulation effort advances ferroelectric-based bioelectromechanical systems and drug delivery platforms.