セッション詳細
[1S-Am(English)][Transformative Research Areas (A)] Prologue to Protein Lifetime Research([学変A] タンパク質寿命学のプロローグ)
2024年7月17日(水) 9:00 〜 11:30
A会場 1F 大会議室101
Organizers:Daisuke Morito(Showa University), Koji Yamano(Tokyo Medical and Dental University)
RNA expressions do not highly correlate with the downstream protein levels. This discrepancy is due to diversities of translation efficiency and protein lifetime. In addition to RNA-seq analysis, innovations of various technologies such as precise measurement and manipulation of protein lifetime make us open up a new protein era. In this symposium, we would like to propose a creation of protein lifetime science, which will shed new light on the chaotic protein world.
[1A01]Control of nascent protein's lifetime through chemical modifications(新生プロテオームの化学修飾による寿命制御)
*Koshi Imami1 (1. RIKEN IMS)
[1A02]Functional analysis of a folding chaperone for RAB GTPases to regulate their protein lifetime(RABタンパク質の寿命を制御するフォールディングシャペロンの機能解析)
*Koji Yamano1 (1. Tokyo Medical and Dental University)
[1A03]The elucidation of the mechanism for the nuclear export of ubiquitinated nascent proteins and its physiological significance(ユビキチン化新生タンパク質の核外搬出機構とその生理的意義の解明)
*Shoshiro Hirayama1, Seito Matsui1, Takahiro Itou1, Shigeo Murata1 (1. The University of Tokyo. Graduate School of Pharmaceutical Sciences,)
[1A04]Proteome remodeling by hyperosmotic stress(高浸透圧ストレスによるプロテオームリモデリング)
*Yasushi Saeki1, Takuya Tomita1 (1. The Institute of Medical Science, The University of Tokyo)
[1A05]Targeted protein degradation with the power of plant (植物の力を利用した標的タンパク質分解)
*Masato Kanemaki1 (1. National Institute of Genetics)
[1A06]Misdirected cell-autonomous immunity targets intrinsic organelles in moyamoya disease.(もやもや病における抗オルガネラ性自己免疫)
*Minami Orii1, Shiori Ainuki1, Daisuke Oikawa2, Akinori Endo3, Fuminori Tokunaga2, Keiji Tanaka3, Yasushi Saeki4, Kazuhiro Nagata5, Daisuke Morito1 (1. Showa University, School of Medicine, 2. Graduate School of Medicine, Osaka Metropolitan University, 3. Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, 4. Division of Protein Metabolism, The Institute of Medical Science, the University of Tokyo, 5. JT Biohistory Research Hall)