Session Details
[1S-Am(English)][Transformative Research Areas (A)] Prologue to Protein Lifetime Research
Wed. Jul 17, 2024 9:00 AM - 11:30 AM JST
Wed. Jul 17, 2024 12:00 AM - 2:30 AM UTC
Wed. Jul 17, 2024 12:00 AM - 2:30 AM UTC
Venue A 1F Conference Room 101
Organizers:Daisuke Morito(Showa University), Koji Yamano(Tokyo Medical and Dental University)
RNA expressions do not highly correlate with the downstream protein levels. This discrepancy is due to diversities of translation efficiency and protein lifetime. In addition to RNA-seq analysis, innovations of various technologies such as precise measurement and manipulation of protein lifetime make us open up a new protein era. In this symposium, we would like to propose a creation of protein lifetime science, which will shed new light on the chaotic protein world.
[1A01]Control of nascent protein's lifetime through chemical modifications
*Koshi Imami1 (1. RIKEN IMS)
[1A02]Functional analysis of a folding chaperone for RAB GTPases to regulate their protein lifetime
*Koji Yamano1 (1. Tokyo Medical and Dental University)
[1A03]The elucidation of the mechanism for the nuclear export of ubiquitinated nascent proteins and its physiological significance
*Shoshiro Hirayama1, Seito Matsui1, Takahiro Itou1, Shigeo Murata1 (1. The University of Tokyo. Graduate School of Pharmaceutical Sciences,)
[1A04]Proteome remodeling by hyperosmotic stress
*Yasushi Saeki1, Takuya Tomita1 (1. The Institute of Medical Science, The University of Tokyo)
[1A05]Targeted protein degradation with the power of plant
*Masato Kanemaki1 (1. National Institute of Genetics)
[1A06]Misdirected cell-autonomous immunity targets intrinsic organelles in moyamoya disease.
*Minami Orii1, Shiori Ainuki1, Daisuke Oikawa2, Akinori Endo3, Fuminori Tokunaga2, Keiji Tanaka3, Yasushi Saeki4, Kazuhiro Nagata5, Daisuke Morito1 (1. Showa University, School of Medicine, 2. Graduate School of Medicine, Osaka Metropolitan University, 3. Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, 4. Division of Protein Metabolism, The Institute of Medical Science, the University of Tokyo, 5. JT Biohistory Research Hall)