講演情報
[E6-4]Efficacy and Safety of Oral Iohexol in the Management of Postoperative Chylous Ascites
Zhixun Zhao1, Yihang Shi1, Haipeng Chen1, Xu Guan1, Zheng Jiang1, Ming Yang1, Henchang Liu1, Jianwei Liang1, Xishan Wang1 (1.Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 2.Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)
Abstract
Background: Chylous ascites (CA) post-abdominal and pelvic surgery presents a significant clinical challenge, often leading to prolonged hospital stays and increased morbidity. Traditional management strategies frequently fall short, necessitating innovative treatment approaches.
Methods: This single-arm prospective clinical trial evaluated the efficacy and safety of oral Iohexol for CA treatment in 30 patients post-pelvic and abdominal surgery. The study employed stringent diagnostic criteria, with intervention measures including oral Iohexol administration, followed by a resolution evaluation system. Non-responsive cases proceeded to interventional lymphangiography and embolization.
Results: Administration of oral Iohexol led to 80% of the cohort reaching Grade A Success, with a notable 33% achieving Grade A+ Success within the inaugural week, showcasing a swift therapeutic impact. Multivariate analysis indicated a lesser response to Iohexol among patients who underwent preoperative treatments or who experienced daily drainage exceeding 500 ml. For these patients, further intervention via lymphangiography was essential, leading to successful embolization in cases of confirmed lumbar trunk injury.
Conclusion: The use of oral Iohexol has proven to be an effective frontline treatment for CA post-surgery, significantly improving resolution rates compared to standard methods. The multivariate analysis indicates that certain patient profiles may require additional interventional treatments, suggesting the need for individualized management plans. These findings advocate for the inclusion of Iohexol in postoperative CA treatment protocols, with potential implications for enhancing patient recovery and outcomes
Background: Chylous ascites (CA) post-abdominal and pelvic surgery presents a significant clinical challenge, often leading to prolonged hospital stays and increased morbidity. Traditional management strategies frequently fall short, necessitating innovative treatment approaches.
Methods: This single-arm prospective clinical trial evaluated the efficacy and safety of oral Iohexol for CA treatment in 30 patients post-pelvic and abdominal surgery. The study employed stringent diagnostic criteria, with intervention measures including oral Iohexol administration, followed by a resolution evaluation system. Non-responsive cases proceeded to interventional lymphangiography and embolization.
Results: Administration of oral Iohexol led to 80% of the cohort reaching Grade A Success, with a notable 33% achieving Grade A+ Success within the inaugural week, showcasing a swift therapeutic impact. Multivariate analysis indicated a lesser response to Iohexol among patients who underwent preoperative treatments or who experienced daily drainage exceeding 500 ml. For these patients, further intervention via lymphangiography was essential, leading to successful embolization in cases of confirmed lumbar trunk injury.
Conclusion: The use of oral Iohexol has proven to be an effective frontline treatment for CA post-surgery, significantly improving resolution rates compared to standard methods. The multivariate analysis indicates that certain patient profiles may require additional interventional treatments, suggesting the need for individualized management plans. These findings advocate for the inclusion of Iohexol in postoperative CA treatment protocols, with potential implications for enhancing patient recovery and outcomes