[2O0101-05] ベストプレゼンテーション賞（BPA）

9:36 〜 9:54

[2O0101-05-03] Combining phenotypic screening with DRUG-seq transcriptomics for efficient selection of anti-Chagas hits with a novel mechanism of action

○Michele Lika Furuya^1,2, Japheth Kibet Ng’etich ^2,4,5,3, Naoya Kadofusa⁶, Ayato Sato^6,7, Jean-Robert Ioset⁸, Takeshi Nara Nara⁹, Takaya Sakura^1,2,10, Daniel Ken Inaoka^1,2,10,11 (1. TMGH, Nagasaki Univ., 2. Dept. of Inf. Bioch., NEKKEN, Nagasaki Univ., 3. Dept. of Mol. Microb. and Imm. Grad. Sch. of Biomed. Sci., Nagasaki Univ., 4. Prog. for Nurturing Global Leaders in Trop. and Emerg. Comm. Dis., Grad. Sch. of Biomed. Sci., Nagasaki Univ., 5. Ctr. for Trad. Med. and Drug Res., Kenya Med. Res. Inst., Kenya, 6. Inst. of Transformative Bio-Mol. (WPI-ITbM), Nagoya Univ., 7. Ctr. for One Med Innov. Trans. Res. (COMIT), Nagoya Univ., 8. Drugs for Neglected Diseases Initiative (DNDi), 9. Lab. of Mol. Parasitology, Grad. Sch. of Life Sci. and Tech., Iryo Sosei Univ., 10. Dept. of Mol. Inf. Dyn., NEKKEN, Nagasaki Univ., 11. Dept. of Biomed. Chem., Grad. Sch. of Med., The Univ. of Tokyo.)

キーワード：

Chagas disease、Phenotypic screening、Trasncriptomics、Drug discovery、DRUG-seq、Mechanism of action

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