Presentation Information
[C08-02]From Signals to Structure: A Computational Framework Linking Multiple Chemical Cues to Cellular Patterning
*Zahra Eidi1, Najme Khorasani1, Mehdi Sadeghi1 (1. School of Biological Sciences, Institute for Research in Fundamental Sciences (IPM) (Iran))
Keywords:
Pattern Formation,Signaling,Cell Development
How do cells interpret a complex landscape of chemical cues to self-organize into structured tissues? This talk offers a computational perspective on the interplay between multiple signaling patterns and the spatial arrangement of differentiated cell types during development. In environments where multiple diffusible signals—modeled via Turing systems—coexist, the model examines how cells use external cues to guide fate decisions through modulation of their internal dynamics. A predictive computational map reveals a consistent correspondence between the signaling landscape and the emergent spatial organization of phenotypes. Furthermore, the framework can be inverted: given a final tissue pattern, it becomes possible to infer plausible signal configurations that may have orchestrated its formation, assuming the underlying signaling dynamics are known.