Presentation Information
[C12-03]Optimizing Therapeutic Strategies to Prevent EMT-Driven Metastasis via β-catenin Control
*SooYoun Choi1, Yunil Roh2, Yong Dam Jeong1, Il Hyo Jung2 (1. Institute of Mathematical Sciences, Pusan National Univ. (Korea), 2. Department of Mathematics, Pusan National Univ. (Korea))
Keywords:
Cancer metastasis,Epithelial–mesenchymal transition (EMT),Cell signaling,Optimal modulation strategies,WNT signaling pathway
Cancer metastasis remains a leading cause of mortality in cancer patients, with dysregulation of the WNT signaling pathway recognized as a key driver. Aberrant activation of this pathway leads to excessive accumulation of β-catenin, which in turn promotes epithelial–mesenchymal transition (EMT), enhancing cell motility and metastatic potential. Although both monotherapy and combination therapies have been developed to suppress elevated β-catenin levels, the complexity of intracellular signaling limits the ability to compare and predict treatment outcomes. Furthermore, determining the optimal dosage ratio for combination therapies remains challenging. In this talk, we address these issues by constructing a mathematical model that integrates the interactions between the WNT signaling pathway and transforming growth factor-β (TGF- β), both central regulators of EMT. Applying optimal control theory, we explore strategies to minimize β-catenin concentration. We evaluate the effectiveness of monotherapy approaches and determine the optimal combination ratio based on E-cadherin expression, a biomarker for EMT suppression. Additionally, we propose optimal treatment protocols that incorporate control sequences and delay times to reduce patient burden while maximizing therapeutic efficacy. Our findings aim to advance the understanding of metastasis-related signaling mechanisms and contribute to the development of improved therapeutic strategies.