[POS] Neurobiology and Brain

[POS-10] Mathematical Modeling of Cell-Cell Adhesion Effects on New Neuron Collectively Migrating or Mutually Restraining

*Katsuyoshi Matsushita¹, Mami Matsumoto², Kazunobu Sawamoto², Koichi Fujimoto¹ (1. Grad. Sch. Integr. Sci. Life, Hiroshima Univ. (Japan), 2. Grad. Sch. Med. Sci., Nagoya City Univ. (Japan))

Keywords:

Neuron migration,Cell-Cell adhesion,Computer simulation,Collective migration

Collective cell migration widely maintains the development and physiological processes of organisms. The collective migration of new neurons is known as a typical migration and maintains brain development and function. This new neuron migration is recognized as a key to treatments for brain injury. This is because the development of guiding the spontaneous new neuron migration to the injured region will open the door for groundbreaking medical treatments. For the development, Matsumoto et al. found cell-cell adhesion due to NCAM as the origin of the new neuron restrainment that inhibits regular collective migration around the injured regions. Based on this finding, they presented a solution that recovers the migration efficiency of new neurons. We develop the mathematical model for this collective migration and restrainment and give a theoretical interpretation of this phenomenon based on a virtual experiment with cell-cell adhesion control. We also discuss the properties of this phenomenon in a general theoretical framework for the cell-cell adhesion effects on collective cell migration.