Presentation Information
[SS17-04]Decoding Rules for Condensation of Disordered Protein Sequences
*Kyosuke Adachi1,2, Kyogo Kawaguchi2,3,4,5 (1. RIKEN Interdisciplinary Theoretical and Mathematical Sciences Program (Japan), 2. RIKEN Center for Biosystems Dynamics Research (Japan), 3. RIKEN Cluster for Pioneering Research (Japan), 4. Institute for Physics of Intelligence, The University of Tokyo (Japan), 5. Universal Biology Institute, The University of Tokyo (Japan))
Keywords:
Protein condensates,Intrinsically disordered region
Protein condensates—such as nucleoli and nuclear speckles—coexist within cells and are pivotal to numerous cellular functions. Although interactions among intrinsically disordered regions are known to drive condensation, the specific rules of amino acid sequences that enable the coexistence of distinct condensates remain elusive. In this presentation, I will outline our theoretical framework for calculating heteropolymer interactions between disordered protein sequences [1]. This approach allows us to predict key condensate properties, including critical temperatures and the conditions necessary for the coexistence of multiple types of condensates.
[1] K. Adachi and K. Kawaguchi, Phys. Rev. X 14, 031011 (2024).
[1] K. Adachi and K. Kawaguchi, Phys. Rev. X 14, 031011 (2024).