[SS21] Transformation and Integration of Data and Modeling in Medicine

[SS21-02] Asthma suppresses optic glioma growth via T cell-derived decorin-mediated inhibition of microglia

*Donggu Lee¹, Yangjin Kim¹ (1. Konkuk University (Korea))

Keywords:

Mathematical oncology,Mathematical modeling,Mathematical biology,Optimal control theory

Optic glioma, a slow-growing tumor associated with NF1 mutations, is driven by dysregulated RAS signaling, leading to increased midkine (MDK) production and tumor progression. While asthma is typically linked to chronic inflammation, our mathematical analysis suggests that it may play an unexpected tumor-suppressive role through immune reprogramming. Specifically, asthma-induced T cell reprogramming promotes the release of decorin, which inhibits CCR8 in microglia, leading to reduced NFkB activity and suppressed CCL5 production, a key driver of glioma growth. Our results indicate that asthma-driven immune modulation can significantly slow tumor progression, suggesting that the systemic effects of asthma may influence tumor microenvironment dynamics. These findings highlight the potential of leveraging asthma-induced immune regulation as a novel mechanism for glioma suppression and demonstrate the power of mathematical modeling in uncovering complex tumor-immune interactions.