[SS22] Understanding complex dynamics of cancer progression and treatment response

[SS22-03] Modeling immune response to radiotherapy

*Wonmo Sung Sung¹ (1. The Catholic University of Korea (Korea))

Keywords:

tumor,radiotherapy,immunotherapy,blood dose

Cancer metastasis is the major cause of cancer mortality, accounting for about 90% of cancer deaths. Although radiation therapy has been considered effective in reducing localized cancer burden, emerging evidence suggests that radiation can potentially turn tumors into an "in situ vaccine." This has raised significant interest in combining radiation with immune checkpoint inhibitors. However, the combination approach might be limited by radiation-induced immunosuppression. Assessing the effects of radiation on the immune system at the patient level is critical to maximizing the systemic antitumor response of radiation. This talk will summarize the developed computational solutions in two different categories for systemic radiation therapy: blood dose and tumor-immune interactions. Clinical evidence supporting these computational solutions will be presented. Additionally, this talk will introduce how these computational tools could be used to optimize radiotherapy regimens and maximize their synergy with immunotherapy.