[SS25] Unravelling Double Trouble: Using Mathematical Models to Tackle Ecological Challenges and Neurological Disorders

[SS25-02] Modeling Biomolecular Condensates at Synapses for Memory Formation

*vikas pandey^1,2, Tomohisa Hosokawa³, Yasunori Hayashi ³, Hidetoshi Urakubo² (1. Osaka University (Japan), 2. Fujita Health University (Japan), 3. Kyoto University (Japan))

Keywords:

Memory Formation,Post Synaptic Density,Biophysics

The protein relocation at synapses generate droplet-like structures called biomolecular condensates, which may play a crucial role in memory formation. Pandey et al. Cell Reports, 2025 show how the proteins organize to create droplet-in-droplet structures at the postsynaptic density and demonstrated the biophysical mechanism using computational modeling. The Monte Carlo simulations show that the shape of the protein is important in the formation of these structures via interfacial tensions. We show, using network analysis, that one of the proteins influences modularity and slow diffusion. This computational method can be used to study other biological systems that exhibit droplet-in-droplet structures.