Session Details

[MS05]Mathematical and biophysical modeling of collective cell migration, fate transition, and heterogeneity in development and diseases

Tue. Jul 8, 2025 4:50 PM - 6:30 PM JST
Tue. Jul 8, 2025 7:50 AM - 9:30 AM UTC
Room 08
Chair:Mubasher Rashid Rather(Indian Institute of Technology Kanpur,India), Ushasi Roy( Indian Institute of Science Education and Research Pune, India)
Cell-cell interactions, collective migration, and fate transitions are at the heart of life’s most intricate processes,from embryonic development to the progression of diseases like cancer. These dynamic behaviors drive tissue organization, repair, and adaptation, while their dysregulation underpins pathologies such as tumor progression and metastasis. Understanding how cells communicate, coordinate their movements, and navigate fate decisions is key to unravelling the molecular and mechanical forces shaping development and diseases.
Mathematical modeling and biophysical approaches offer powerful framework to decipher these complexities. By combining quantitative tools with experimental data, we can unravel the interplay of biochemical signaling, mechanical forces, and emergent population behaviors. These approaches illuminate how cells migrate collectively during development or metastasis, how fate decisions arise from dynamic gene regulatory networks, and how heterogeneity fosters adaptability in diverse contexts.
This mini-symposium will showcase cutting-edge mathematical and biophysical approaches to study these crucial cellular processes. Presentations will explore quantitative models of cell-cell interactions, migration, fate transitions, and heterogeneity, with a goal of advancing our understanding of cellular dynamics and informing the development of novel therapeutic strategies for diseases like cancer and tissue regeneration.

[MS05-03]Structure formation induced by non-reciprocal cell–cell
interactions in a multicellular system

*Biplab Bhattacherjee1, Masayuki Hayakawa1, Tatsuo Shibata1 (1. RIKEN Center for Biosystems Dynamics Research (Japan))

[MS05-04]Emergence of metabolic strategies in a consumption-secretion model of a cancer cell community

*B Vibishan1, Mohit Kumar Jolly1, Akshit Goyal2 (1. IISc Bengaluru (India), 2. International Centre for Theoretical Physics Bengaluru (India))