[1C01-07] Environmental Radiation

10:15 AM - 10:30 AM JST(1:15 AM - 1:30 AM UTC)

[1C02] Construction and Simulation Validation of a Mathematical Model of DNA Double-Strand Breaks

*Shotaro Fujita¹, Fuminobu Sato¹, Yoko Akiyama¹, Yuichiro Manabe¹ (1. Osaka University Graduate School of Engineering Division of Sustainable Energy and Environmental Engineering)

Keywords:

DNA double-strand breaks (DSBs),Mathematical model,Radiation exposure,Monte Carlo simulations,Parameter optimization,Error range,Biological experimental data,Predictive accuracy,Radiation therapy,Minimizing side effects

The primary objective of this study is to develop a mathematical model to predict the number of DNA double-strand breaks (DSBs) occurring in cells during radiation exposure. This model aims to provide more accurate predictions of radiation therapy effects and lay the groundwork for designing optimal treatments. Previous models used simple fitting methods, raising doubts about their predictive accuracy and reliability. Our study employs Monte Carlo simulations to determine optimal parameter values and evaluate their validity. By quantitatively assessing the model's error range and comparing predictions with biological experimental data, we aim to enhance the model's accuracy. This model is expected to improve understanding of radiation-induced DNA damage and optimize radiation therapy planning, minimizing side effects for patients.