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Mon. Mar 17, 2025

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Use of human/animal intestinal stem cells derived from crypts and their differentiated cells for the evaluation of intestinal absorption and toxicity of drugs

Joint Session : The Japanese Society for Alternatives to Animal Experiments

Based on the 3Rs and animal alternative methods, technological innovations in human biology are occurring by using New Approach Methodologies, such as human tissues, differentiated cells from human iPS cells, organoids, organ chips, and 3D printing. In addition, the FDA Modernization Act 2.0 has been issued to promote human cell-based evaluation systems for pharmaceutical drugs instead of traditional animal studies. In this symposium, we will discuss strategies to apply human cells for understanding human organ biology, drug development and regenerative medicine. We hope to provide an opportunity to deepen our understanding of human biology by discussing cutting-edge findings from the perspectives of industry, government, and academia. This would allow participants to promote understanding of human biology in the scientific communities, such as alternative methods and human tissues, as well as issues and future prospects.

New trend of human biology using human tissue models

APPW2025

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[[OD]1S14m-4]Use of human/animal intestinal stem cells derived from crypts and their differentiated cells for the evaluation of intestinal absorption and toxicity of drugs

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