Session Details

[1S14m]New trend of human biology using human tissue models

Mon. Mar 17, 2025 8:30 AM - 10:20 AM JST
Mon. Mar 17, 2025 11:30 PM - 1:20 AM UTC
Room 14
Oranizers :Yasunari Kanda (Division of Pharmacology, National Institute of Health Sciences) and Yasuhiro Tsukimi (ASKA Pharmaceutical Co., Ltd.)
Joint Session : The Japanese Society for Alternatives to Animal Experiments
Based on the 3Rs and animal alternative methods, technological innovations in human biology are occurring by using New Approach Methodologies, such as human tissues, differentiated cells from human iPS cells, organoids, organ chips, and 3D printing. In addition, the FDA Modernization Act 2.0 has been issued to promote human cell-based evaluation systems for pharmaceutical drugs instead of traditional animal studies. In this symposium, we will discuss strategies to apply human cells for understanding human organ biology, drug development and regenerative medicine. We hope to provide an opportunity to deepen our understanding of human biology by discussing cutting-edge findings from the perspectives of industry, government, and academia. This would allow participants to promote understanding of human biology in the scientific communities, such as alternative methods and human tissues, as well as issues and future prospects.

[1S14m-1]Global trends in drug development using alternatives to animal testing

Yasunari Kanda (Division of Pharmacology, National Institute of Health Sciences)
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[[OD]1S14m-2]Revolutionizing Physiology: Advances in Organ-on-a-Chip Technology

Ken Takahashi (Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences)
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[1S14m-3]Constructing Neural Circuits by Connecting Organoids

Yoshiho Ikeuchi (Institute of Industrial Science, The University of Tokyo)
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[[OD]1S14m-4]Use of human/animal intestinal stem cells derived from crypts and their differentiated cells for the evaluation of intestinal absorption and toxicity of drugs

Kazuya Maeda (School of Pharmacy, Kitasato University)
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[1S14m-5]A novel in vitro 3D bioprinted liver fibrosis model consisted of human hepatocytes to predict hepatotoxicity, efficacy and MOA of potential therapeutic reagent for steatotic liver disease

Toshihiko Maekawa, Ayu Inoue, Shizuka Akieda (Cyfuse Biomedical K.K.)
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