Session Details
[1S07a]Molecular Insights into Aortic Disease: New Preventive and Therapeutic Frontiers
Mon. Mar 17, 2025 1:40 PM - 3:30 PM JST
Mon. Mar 17, 2025 4:40 AM - 6:30 AM UTC
Mon. Mar 17, 2025 4:40 AM - 6:30 AM UTC
Room 7
Oranizers :Utako Yokoyama (Department of Physiology, Tokyo Medical University) and Kazuaki Yoshioka (Department of Physiology, Kanazawa University Graduate School of Medical Sciences)
The aorta is the largest blood vessel in the human body, branching directly from the heart, and is the main trunk tissue in blood circulation. In our super-aging society, preventing, early detection, and treatment of fatal aortic diseases such as aortic aneurysms and dissections, which have been increasing in recent years, is a crucial issue. Recent exciting advancements in high-resolution multi-color imaging technologies and multi-omics analysis methods have elucidated the previously unknown causes and pathophysiological mechanisms of aortic diseases. In this symposium, researchers who are attempting to elucidate the pathophysiology of aortic diseases from novel molecular and cellular perspectives will present their cutting-edge work. We will share the latest findings on the mechanisms maintaining homeostasis through intercellular interactions in aortic tissue. We hope to catalyze insights that discuss future prospects for overcoming these diseases from multiple angles. Ultimately, this symposium endeavors to forge a path towards improved preventative measures, earlier diagnoses, and more effective therapeutic interventions for aortic pathologies.
[1S07a-1]Single-cell RNA-seq analysis of adventitial vasa vasorum in human acute aortic syndrome
○Kazuaki Yoshioka, Kenji Iino, Yukinobu Itoh, Tomoaki Matsuyama, Kanora Kobayashi, Beta C. Harlyjoy, Aya Matsui, Hitoshi Ando, Hisamichi Naito (Kanazawa University)
[[OD]1S07a-2]Perivascular Adipose Tissue As a Therapeutic Target in Vascular Diseases
○Kazutaka Ueda1,2 (1.International University of Health and Welfare, 2.The University of Tokyo Graduate School of Medicine)
[1S07a-3]Mechano-sensitive TRPV4 signaling pathway involved in progression of abdominal aortic aneurysm
○Hana Inoue1, Michiko Tashiro1, Hiyo Obikane2, Toshitaka Nagao2, Utako Yokoyama1 (1.Department of Physiology, Tokyo Medical University, 2.Department of Anatomic Pathology, Tokyo Medical University)
[[OD]1S07a-4]Abdominal aortic aneurysm – pathogenesis, prevention, and treatment –
○Nobuhiro ZAIMA1,2 (1.Kindai university, 2.Agricultural Technology and Innovation Research Institute, Kindai University)