APPW2025

Oranizers :Non Miyata (Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases) and Masafumi Noguchi (Laboratory of Pharmacology, School of Pharmaceutical Sciences, Wakayama Medical University)

Mitochondria are dynamic intracellular organelles that autonomously undergo cycles of fusion and fission, maintaining cellular homeostasis through selective autophagic degradation (mitochondrial dynamics). Recent advances in pathobiology have spotlighted mitochondrial dynamics for their pivotal role in orchestrating cellular responses, including apoptosis and differentiation. By modulating metabolic pathways, these processes significantly influence cellular and organismal fate. This symposium will delve into the adaptive responses of mitochondria to extracellular signals, focusing on how mitochondria alter their morphology and metabolism to influence cellular functions in adult tissues. We will discuss the intricate regulatory mechanisms that govern mitochondrial behavior, elucidating their critical roles in tissue physiology. Additionally, we aim to identify potential molecular targets for disease therapy and discuss cutting-edge intervention strategies, including mitochondrial transfer technology. This comprehensive exploration will provide valuable insights into the therapeutic potential of targeting mitochondrial dynamics in various pathological conditions. By fostering international discussions, particularly among young researchers, this symposium aims to chart the future of mitochondria-targeted therapeutic approaches.