[3S03m] Hibernation Biology: Physiological Mechanisms of Active Hypometabolism-Hypothermia | APPW2025

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Symposium

[3S03m]Hibernation Biology: Physiological Mechanisms of Active Hypometabolism-Hypothermia

Wed. Mar 19, 2025 8:30 AM - 10:20 AM JST
Wed. Mar 19, 2025 11:30 PM - 1:20 AM UTC

Room 3

Oranizers :Ryosuke Enoki (ExCELLS/NIPS, NINS) and Genshiro Sunagawa (RIKEN Center for Biosystems Dynamics Research)

Sponsored by : Hibernation Biology 2.0

Mammals are "homeotherms," maintaining their body temperature in a very narrow range around 37°C. If their body temperature changes even a few degrees outside this range, physiological functions immediately collapse, disrupting systemic homeostasis and causing irreversible damage. In some animal species, however, body temperature and metabolism are actively reduced, triggering "hibernation or torpor" in the harsh winter environment when the body's heat production source is unavailable. Most hibernation research to date has been limited to observational descriptions, and most of the physiological functions and mechanisms of hibernation and torpor remain unresolved. In this symposium, researchers from various fields will present the latest findings on hibernation and torpor, biological mechanisms, and discuss the future direction of hibernation biology.

8:31 AM - 8:51 AM JST(11:31 PM - 11:51 PM UTC)

[3S03m-1]Characteristics of lipid metabolism during hibernation in the Syrian hamster.

^○Akari Yamauchi^1,2, Junpei Yamashita¹, Yuki Sugiura³, Yuta Matsuoka³, Masamitsu Sone^1,2, Yoshifumi Yamaguchi^1,2 (1.Hibernation metabolism, physiology, and development Group, Inst. Low Temp. Sci., Hokkaido Univ., 2.Biosphere Science, Grad. Sch. Env. Sci., Hokkaido Univ., 3.Grad. Sch. Med., Kyoto Univ.)

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8:51 AM - 9:11 AM JST(11:51 PM - 12:11 AM UTC)

[3S03m-2]Maintenance of skeletal muscle homeostasis in hibernating animals through active hypometabolism

^○Mitsunori Miyazaki (Department of Integrative Physiology, Graduate School of Biomedical and Health Sciences, Hiroshima University)

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9:11 AM - 9:31 AM JST(12:11 AM - 12:31 AM UTC)

[3S03m-3]Bidirectional interactions between gut microbes and host energy metabolism under artificial hibernation

^○Reina Miyajima¹, Takahiro Yamada², Genshiro Sunagawa^3,4, Takeshi Sakurai⁵, Koji Hase¹ (1.Division of Biochemistry, Graduate School of Pharmaceutical Science, Keio University, Tokyo, Japan, 2.Department of Immunology, Yale School of Medicine, 3.Laboratory for Hibernation Biology, RIKEN Center for Biosystems Dynamics Research, 4.Suntory SunRiSE Fellow, Suntory Foundation for Life Sciences, 5.Institute of Medicine/WPI-IIIS, University of Tsukuba)

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9:31 AM - 9:51 AM JST(12:31 AM - 12:51 AM UTC)

[3S03m-4]Body temperature regulates glucose metabolism

^○Ming-Liang Lee^1,2, Ching-Pu Ching-Pu^1,2, Chitoku Toda³, Tomomi Nemoto^1,2, Ryosuke Enoki^1,2 (1.The Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, 2.National Institute for Physiological Sciences, National Institutes of Natural Sciences, 3.Faculty of Life Sciences,Kumamoto University)

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9:51 AM - 10:20 AM JST(12:51 AM - 1:20 AM UTC)

[[OD]3S03m-5]Noninvasive Induction of a Torpor-like Hypometabolic State through Ultrasound Stimulation of the Hypothalamus

^○Hong Chen (Washington University in St. Louis)

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