Presentation Information

11:00 AM - 11:10 AM JST(2:00 AM - 2:10 AM UTC)Japanese

[H931-3am-12]Synthesis of 5-methyluridine derivatives with sulfonamide or sulfonate modifications on the 2´ hydroxyl group and evaluation of their ability to form duplex chains

○Shuntaro Takigawa¹, Takahito Tomori¹, Koya Uekusa¹, Yoshiaki Masaki¹, Kohji Seio¹ (1. Sch. Life Sci. Tech., Tokyo Tech.)

Antisense oligonucleotides,Duplex melting temperature,Modified nucleic acid,Sulfonamide modification,Sulfonyl fluoride modification