[[A]A404-1pm] 16. Natural Products Chemistry, Chemical Biology

2:10 PM - 2:30 PM JST(5:10 AM - 5:30 AM UTC)Japanese

[[A]A404-1pm-04] Development of brain-permeable metabotropic glutamate receptor subtype 1 (mGlu1)-selective allosteric ligands and their application to in vivo chemogenetic control of mGlu1

○Tomohiro Doura¹, Takumi Kondo¹, Keigo Morikawa², Tomoteru Yamasaki³, Masayuki Fujinaga³, Ming-Rong Zhang³, Wataru Kakegawa⁴, Shigeki Kiyonaka^1,5 (1. Graduate School of Engineering, Nagoya University, 2. School of Engineering, Nagoya University, 3. National Institutes for Quantum Science and Technology, 4. Keio University School of Medicine, 5. Research Institute for Quantum and Chemical Innovation, Institutes of Innovation for Future Society, Nagoya University)

Keywords:

chemogenetics,G protein-coupled receptor,pharmacokinetics,motor learning,blood-brain barrier permeability