[3S14a] Cutting-edge research for development of diagnosis and therapeutics for Alzheimer's disease

2:35 PM - 3:05 PM JST(5:35 AM - 6:05 AM UTC)

[3S14a-03] Tangle formation of Alzheimer's disease-fold Tau filaments by the negatively charged fuzzy coat

^○Shingo Tamai^1,2, Takashi Nomura¹, Ryohei Kojima³, Ryo Fujioka⁴, John Burke¹, Atsushi Yamagata⁵, Mikako Shirouzu⁵, Takeshi Fukuma³, Hiroki Sasaguri⁴, Motomasa Tanaka^1,2 (1.Lab. for Protein Conformation Diseases, RIKEN CBS, 2.Graduate School of Medical & Dental Sciences, TMDU, 3.WPI-NanoLSI, Kanazawa Univ., 4.Dementia Pathophysiology Collaboration Unit, RIKEN CBS, 5.Lab. for Protein Functional and Structural Biology, RIKEN BDR)

キーテクノロジー：cryo-EM & FM-3D-AFM

Keywords:

fuzzy coat、tau、hyperphosphorylation

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