Session Details
[1T14]Signal Transduction
Wed. Nov 6, 2024 11:05 AM - 12:35 PM JST
Wed. Nov 6, 2024 2:05 AM - 3:35 AM UTC
Wed. Nov 6, 2024 2:05 AM - 3:35 AM UTC
Room14(G319)
Organizers: Junji Yamauchi(Tokyo University of Pharmacy and Life Sciences), Kenji Kontani(Meiji Pharmaceutical University)
[1T14-01]Inhibition of cancer cells growth by novel inhibitors targeting the Ser/Thr phosphatase PPM1D
○Yuta Irifune1, Sari Ogasawara1, Keiji Tanino2, Rui Kamada1, Kazuyasu Sakaguchi1 (1.Laboratory of Biological Chemistry, Department of Chemistry, Faculty of Science, Hokkaido University, 2.Laboratory of Organic Chemistry II, Department of Chemistry, Faculty of Science, Hokkaido University)
キーテクノロジー:構造活性相関解析
[1T14-02]Biochemical analysis to elucidate the novel regulatory mechanism of CaMKKbeta
○Satomi Ohtsuka, Naoya Hatano, Masaki Magari, Hiroshi Tokumitsu (Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University)
キーテクノロジー:リン酸化反応
[1T14-03]Essential roles of endothelial RhoA in vascular development for regulation of stalk cell differentiation via Notch1 expression
○Wondwossen Wale Tesega, Akio Shimizu, Ogita Hisakazu (Molecular Medical Biochemistry, Shiga University of Medical Science)
キーテクノロジー:Endothelial-specific KO mouse
[1T14-04]Flavonoid as a ligand of GPR35
○Fumie Nakashima1, Sayako Shimomura1, Harumi Ando1, Asuka Inoue2, Koji Uchida3, Takahiro Shibata1 (1.Graduate School of Bioagricultural Sciences, Nagoya University, 2.Graduate School of Pharmaceutical Sciences, Tohoku University, 3.Graduate School of Agricultural and Life Sciences, The University of Tokyo)
キーテクノロジー:ドッキングシミュレーション
[1T14-05]Chemogenetic activation of G12 signaling in the liver causes liver enlargement
○Maho Kitagawa1, Kaito Arai1, Asuka Inoue1,2 (1.Graduate School of Pharmaceutical Sciences, Tohoku University, 2.Graduate School of Pharmaceutical Sciences, Kyoto University)
キーテクノロジー:ケモジェネティクス
[1T14-06]Novel positive regulator of Hedgehog signaling via phosphorylation of GLI2/GLI3
○Saishu Yoshida1,2, Akira Kawamura2, Katsuhiko Aoki3, Pattama Wiriyasermkul4,5, Shinya Sugimoto6,7,8, Junnosuke Tomiyoshi2, Ayasa Tajima4,9, Yamato Ishida10, Yohei Katoh10,11, Takehiro Tsukada1, Yousuke Tsuneoka12, Kohji Yamada2, Shushi Nagamori4,5, Kazuhisa Nakayama10, Kiyotsugu Yoshida2 (1.Department of Biomolecular Science, Toho University, 2.Department of Biochemistry, The Jikei University School of Medicine, 3.Radioisotope Research Facilities, The Jikei University School of Medicine, 4.Center for SI Medical Research, The Jikei University School of Medicine, 5.Department of Laboratory Medicine, The Jikei University School of Medicine, 6.Department of Bacteriology, The Jikei University School of Medicine, 7.Center for Biofilm Science and Technology, The Jikei University School of Medicine, 8.Laboratory of Amyloid Regulation, The Jikei University School of Medicine, 9.Department of Molecular Biology, The Jikei University School of Medicine, 10.Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, 11.Hiroshima University Genome Editing Innovation Center, 12.Department of Anatomy, Faculty of Medicine, Toho University)
キーテクノロジー:Interactome
[1T14-07]Structure-activity relationship studies of pyrogallol as a calcineurin/NFAT signaling suppressor
○Hiroyuki Mizuguchi1, Tomohira Ito2, Kohei Nishida2, Tomoharu Wakugawa2, Tomohiro Nakano2, Akie Tanabe1, Tomokazu Watano1, Osamu Kaminuma3, Noriko Kitamura4, Tatsuya Ishida5, Katsunori Kimura6, Yoshiaki Kitamura7, Noriaki Takeda7, Hiroyuki Fukui8 (1.Laboratory of Pharmacology Faculty of Pharmacy Osaka Ohtani University, 2.Department of Molecular Pharmacology, Tokushima University, 3.Department of Disease Model Research Institute of Radiation Biology and Medicine, Hiroshima University, 4.Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science, 5.Faculty of Health and Sports Sciences, Toyo University, 6.Food Microbiology and Function Research Laboratories, R & D Division. Meiji Co., Ltd, 7.Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School, 8.Medical Corporation Kinshukai)
キーテクノロジー:リアルタイムPCR
[1T14-08]YAP, an effector molecule in the Hippo signaling pathway, regulates Notch signaling by modulating the expression of Nicastrin, a key component of γ-secretase.
○Yuichiro Kaibori1, Akira Miyazaki1, Ren Wakamura1, Takahisa Kuga1, Nobuyuki Yamagishi1, Daisuke Nagakubo2 (1.Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 2.Division of Health and Hygienic Sciences, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University)
キーテクノロジー:WB、CRISPR-Cas9
[1T14-09]Analysis of the mechanism underlying FGF18-induced liver fibrosis
○Takao Seki1, Yuichi Tsuchiya2, Takashi Nishina1, Sachiko Komazawa1, Hiroyasu Nakano1 (1.Department of Biochemistry, Faculty of Medicine, Toho University, 2.Department of Biochemistry, Faculty of Pharmaceutical Sciences, Toho University)
キーテクノロジー:single cell RNA-seq解析
[1T14-10]Loss of the TMEPAI gene suppresses small intestinal adenoma formation.
○Arisu Mori1, Yuki Matsumoto1, Hiroshi Iida1, Fuma Nitta1, Naoko Nakano1, Susumu Itoh1, Yukihide Watanabe3, Makoto M. Taketo4, Mitsuyasu Kato3, Fumiko Itoh2 (1.Laboratory of Biochemistry, Showa Pharmaceutical University, 2.Laboratory of Stem Cell Regulations, Tokyo University of Pharmacy and Life Sciences, 3.Laboratory of Experimental Pathology Institute of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba, 4.Medical Research Institute KITANO HOSPITAL)
キーテクノロジー:intestinal organoid