[3SL06] Analysis example using time-lapse imaging of human cancer organoids

12:00 PM - 12:20 PM JST(3:00 AM - 3:20 AM UTC)

[3SL06-01] Diversity of patient-derived cancer organoids: permeability, stiffness, and gene expression

Shotaro Tanaka (Tokyo Women's Medical University, Department of Biochemistry)

Cancer organoids prepared from patient tumor tissue maintain the diversity of tumor cells that is lost in cell lines. In this study, we will utilize this characteristic, and use cancer organoids as a research model to clarify how differences in substance permeability in tumor tissue are formed.Currently, we are using four types of colon cancer organoids derived from different patients to measure substance permeability and stiffness, and examining the correlation with gene expression.The results of this study are expected to contribute to proposing methods to improve drug penetration into tumors and to the development of antitumor drugs that penetrate deeper into tumors more efficiently.In this presentation, we will introduce each measurement technology and report on the findings obtained so far.