The 98th Annual Meeting of the Japanese Biochemical Society
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Session Details

Symposium

[1S09m]Molecular basis of multiple physiological functions by the CNC-sMAF transcription factors

Mon. Nov 3, 2025 9:00 AM - 11:00 AM JST
Mon. Nov 3, 2025 12:00 AM - 2:00 AM UTC
Room9(Room 104)
Organizers：Fumiki Katsuoka（Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University）, Takafumi Suzuki（Tohoku University）
9:00 AM - 9:02 AM JST(12:00 AM - 12:02 AM UTC)

[1S09m-00]Introduction

○Takafumi Suzuki (Tohoku University)
Comment()
9:02 AM - 9:25 AM JST(12:02 AM - 12:25 AM UTC)

[1S09m-01]Molecular Mechanisms and Physiological Roles of the KEAP1-NRF2 Regulatory System

○Takafumi Suzuki, Masayuki Yamamoto (Tohoku University)
キーテクノロジー：結晶構造解析、遺伝子改変マウス
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9:25 AM - 9:48 AM JST(12:25 AM - 12:48 AM UTC)

[1S09m-02]Discovery of CH7450924, an NRF2 Activator Targeting KEAP1-NRF2 Protein-Protein Interaction (PPI), and Its Efficacy in Preclinical Multiple Organ Dysfunction Syndrome Models

○Yukari Yasui1, Masaki Hoshino2, Shun Mistumata1, Atsushi Kimbara1, Takeo Harada1, Naoshi Horiba1 (1.Research Division, Chugai Pharmaceutical Co., Ltd., 2.Chugai Research Institute for Medical Science, Inc.)
キーテクノロジー：創薬
Comment()
9:48 AM - 10:11 AM JST(12:48 AM - 1:11 AM UTC)

[1S09m-03]Yin-Yang regulatory dynamic of NRF1 through N-glycosylation

○Yukiko Yoshida (Tokyo Metropolitan Institute of Medical Science)
キーテクノロジー：分子生物学
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10:11 AM - 10:34 AM JST(1:11 AM - 1:34 AM UTC)

[1S09m-04]Nrf3 drives cancer immune evasion via MHC-I degradation

○Tsuyoshi Waku (Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University)
キーテクノロジー：OT-Iマウス解析
Comment()
10:34 AM - 10:57 AM JST(1:34 AM - 1:57 AM UTC)

[1S09m-05]Molecular Basis of Transcriptional Regulation by Dimers Involving Small Maf Proteins

○Fumiki Katsuoka (Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku Univ.)
キーテクノロジー：分子生物学
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10:57 AM - 11:00 AM JST(1:57 AM - 2:00 AM UTC)

[1S09m-06]Discussion

○Fumiki Katsuoka (Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku Univ.)
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