[2S12m] Chemistry and Biochemistry of Chromatin Modification | The 98th Annual Meeting of the Japanese Biochemical Society

Session Details

Symposium

[2S12m]Chemistry and Biochemistry of Chromatin Modification

Tue. Nov 4, 2025 8:45 AM - 10:45 AM JST
Tue. Nov 4, 2025 11:45 PM - 1:45 AM UTC

Room12(Room H)

Organizers：Takashi Umehara（College of Pharmaceutical Sciences, Ritsumeikan University）, Shigehiro Kawashima（Graduate School of Pharmaceutical Sciences, The University of Tokyo）

8:45 AM - 9:07 AM JST(11:45 PM - 12:07 AM UTC)

[2S12m-01]Development of a novel technology to modify intracellular chromatin

^○Shigehiro Kawashima (Graduate School of Pharmaceutical Sciences, The University of Tokyo)

キーテクノロジー：人工的ヒストン修飾導入技術

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9:07 AM - 9:26 AM JST(12:07 AM - 12:26 AM UTC)

[2S12m-02]One-pot peptide ligation accelerating chemical synthesis of ubiquitinated histones

^○Gosuke Hayashi (Nagoya University)

キーテクノロジー：タンパク質化学合成

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9:26 AM - 9:45 AM JST(12:26 AM - 12:45 AM UTC)

[2S12m-03]Structural and functional characterization of histone acetyltransferase p300 bound to acetylated nucleosomes

^○Suguru Hatazawa¹, Mohamad Zandian², Masaya Hashimoto³, Longxia Xu⁴, Eri Ito^1,5, Jiuyang Liu², Genki Nakamura³, Mitsuo Ogasawara¹, Gosuke Hayashi³, Yoshimasa Takizawa¹, Xiaobing Shi⁴, Tatiana G. Kutateladze², Hitoshi Kurumizaka^1,5 (1.Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 2.Department of Pharmacology, University of Colorado School of Medicine, 3.Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, 4.Department of Epigenetics, Van Andel Institute, 5.Department of Biological Sciences, Graduate School of Science, The University of Tokyo)

キーテクノロジー：クライオ電子顕微鏡

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9:45 AM - 10:04 AM JST(12:45 AM - 1:04 AM UTC)

[2S12m-04]Catalytic activity of the histone H3K36 methyltransferase NSD2 depends on the chromatin structure

^○Kiyoe Ura (Graduate school of Science, Chiba University)

キーテクノロジー：ヒストンメチル化活性測定

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10:04 AM - 10:23 AM JST(1:04 AM - 1:23 AM UTC)

[2S12m-05]Genetic introduction of post-translational modification and its applications

^○Takashi Umehara (College of Pharmaceutical Sciences, Ritsumeikan University)

キーテクノロジー：翻訳後修飾

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10:23 AM - 10:45 AM JST(1:23 AM - 1:45 AM UTC)

[2S12m-06]Reconstitution and characterization of gene-scale chromatin with defined modification patterns

^○Yohsuke Fukai^1,2, Tomoya Kujirai³, Masatoshi Wakamori², Setsuko Kanamura^1,2, Lisa Yamauchi^1,2, Somayeh Zeraati^1,2, Satoshi Morita⁴, Chiharu Tanegashima², Mitsutaka Kadota², Mikako Shirouzu⁴, Hitoshi Kurumizaka³, Takashi Umehara^2,5, Kyogo Kawaguchi^1,2,6 (1.RIKEN Pioneering Research Institute, 2.RIKEN Center for Biosystems Dynamics Research, 3.Institute for Quantitative Biosciences, 4.RIKEN Center for Integrative Medical Sciences, 5.Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, 6.Institute for Physics of Intelligence)

キーテクノロジー：クロマチン再構成

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