The 98th Annual Meeting of the Japanese Biochemical Society
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Session Details

Talk

[2T20]Medical Inovation 01

Tue. Nov 4, 2025 10:50 AM - 11:50 AM JST
Tue. Nov 4, 2025 1:50 AM - 2:50 AM UTC
Room20(Room 555)
Organizers：Chojiro Kojima（Yokohama National University）, Kanta Tsumoto（Mie University）
10:50 AM - 11:00 AM JST(1:50 AM - 2:00 AM UTC)

[2T20-01]Dynamics-Based Characterization of the Binding Mechanism of Modified FcRn Ligands to IgG1

○Jingwen Li1, Hirofumi Kosuge1, Satoru Nagatoishi2, Linko Hirono3, Ryoko Otake3, Tatsuya Yumoto3, Yosuke Terao3, Teruhiko Ide3, Kouhei Tsumoto1,2,4 (1.Department of Bioengineering, School of Engineering, The University of Tokyo, 2.Medical Device Development and Regulation Research Center, School of Engineering, The University of Tokyo, 3.Tosoh Corporation, 4.The Institute of Medical Science, The University of Tokyo)
キーテクノロジー：水素/重水素交換質量分析法
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11:00 AM - 11:10 AM JST(2:00 AM - 2:10 AM UTC)

[2T20-02]Analysis of the OPG-RANKL binding affinity using Gaussia luciferase-based bioluminescence in living cells

○Shinji Fukuda1, Yuto Shibata2, Hisayo Nishida-Fukuda1, Hironao Nakayama3, Takuma Sato2, Ken Miyazawa2, Takahiro Suzuki1 (1.Department of Biochemistry, School of Dentistry, Aichi Gakuin University, 2.Department of Orthodontics, School of Dentistry, Aichi Gakuin University, 3.Department of Medical Science and Technology, Hiroshima International University)
キーテクノロジー：生物発光
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11:10 AM - 11:20 AM JST(2:10 AM - 2:20 AM UTC)

[2T20-03]Screening of a Mirror-Image VHH antibody with VEGF-inhibitory activity and evaluation of its immunogenicity

○Kayuu Maeda1, Keisuke Aoki2,3, Manrei Yonemura3, Naoya Iwamoto2,3, Asako Manabe1, Saaya Imahori1, Katsuaki Higashi1, Shogo Oka1,4, Jyoji Morise1, Shinya Oishi2,3, Motohiro Nonaka1 (1.Human Health Sciences Dept. Med., The Univ. of Kyoto, 2.Organic Chemistry Dept. Pharm., The Univ. of Kyoto, 3.Pharmaceutical Chemistry Dept. Drug Discovery Science., The Univ. of Kyoto Pharmaceutical, 4.Medical Sciences Dept.The Univ. of Fujita Health)
キーテクノロジー：鏡像スクリーニング
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11:20 AM - 11:30 AM JST(2:20 AM - 2:30 AM UTC)

[2T20-04]CDR grafting into light chain recombinant antibodies and evaluation of antigen binding affinity

○Hinako Shida1, Yuki Anraku1, Takuto Kumagai1, Ryu Sugawa1, Masato Sumi1, Taishi Onodera5, Yu Adachi5, Saya Moriyama5, Yoshimasa Takahashi5, Shunsuke Kita1, Katsumi Maenaka1,2,3,4 (1.Facul. Pharm. Sci., Hokkaido Univ., 2.Inter. Inst. Zoonosis Control, Hokkaido Univ., 3. Inst. Vaccine Res. & Devel., Hokkaido Univ., 4.Facul. Pharm. Sci., Kyushu Univ., 5.Japan Institute for Health Security. / National Institute of Infectious Diseases.)
キーテクノロジー：抗体エンジニアリング技術
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11:30 AM - 11:40 AM JST(2:30 AM - 2:40 AM UTC)

[2T20-05]mRNA delivery using SARS-CoV-2 spike protein-loaded extracellular vesicles

○Yuna Nakagawa1, Yoshimasa Kawaguchi1, Hisaaki Hirose1, Joseph Lee2, Akitsu Hotta2, Takao Hashiguchi3, Shiroh Futaki1 (1.Institute for Chemical Research, Kyoto University, 2.Center of iPS Cell Research and Application, Kyoto University, 3.Institute for Life and Medical Sciences, Kyoto University)
キーテクノロジー：mRNA送達
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11:40 AM - 11:50 AM JST(2:40 AM - 2:50 AM UTC)

[2T20-06]Biological evaluation of the site-specific ADC synthesized by one-pot glycan remodeling.

○Yoshio Takada1, Wataru Tsukimura1, Kento Mori1, Noritaka Hashii2, Akiko Ishii-Watabe2, Tomokazu Sugi1, Mamoru Mizuno1, Kohtaro Goto1 (1.The Noguchi Institute, 2.National Institute of Health Sciences)
キーテクノロジー：位置選択的抗体薬物複合体
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