Session Details
[3S11m]Digging the DUB Family: from structure and physiological function to involvement in stress and disease
Wed. Nov 5, 2025 8:45 AM - 10:45 AM JST
Wed. Nov 5, 2025 11:45 PM - 1:45 AM UTC
Wed. Nov 5, 2025 11:45 PM - 1:45 AM UTC
Room11(Room G)
Organizers：Daisuke Oikawa（Department of Medical Biochemistry, Graduate School of Medicine, Osaka Metropolitan University）, Hirotaka Takahashi（Division of Cell-Free Sciences, Proteo-Science Center (PROS), Ehime University）
Sponsored by：PROS Joint Research Program for Protein Interactome (PRiME), Ehime University
[3S11m-00]Introduction
○Daisuke Oikawa (Department of Medical Biochemistry, Graduate School of Medicine, Osaka Metropolitan University)
[3S11m-01]Mechanisms regulating USP48 activity and its dysregulation by Cushing's disease-associated mutations
○Toshiaki Fukushima1, Gai Ando1, Kei Moritsugu2, Akinori Kidera3, Keijun Kakihara1, Masayuki Komada1 (1.Institute of Science Tokyo, 2.Osaka Metropolitan University, 3.Yokohama City University)
[3S11m-02]Mechanism of ubiquitin chain recognition by UCH37-RPN13 for discriminating homotypic and branched ubiquitin chains.
○Honoka Tokuhisa1, Atsushi Funaguchi2, Moe Miyano2, Naosuke Yoshioka2, Tomoya Hino1,2,3, Shingo Nagano1,2,3, Yusuke Sato1,2,3 (1.Grad. Sch. of Eng., Tottori Univ., 2.Fac. of Eng., Tottori Univ., 3.Cent. for Res. on GSC., Tottori Univ.)
キーテクノロジー：X線結晶構造解析
[3S11m-03]MS-based study of K63 linkage-specific deubiquitinases, AMSH and AMSH-LP
○Akinori Endo (Dept. of Basic Med. Sci., TMiMS)
キーテクノロジー：プロテオミクス
[3S11m-04]The K29/K48 branched ubiquitin chains promote degradation of deubiquitylase-protected
○Mai Morita1,2, Fumiaki Ohtake1,2 (1.Institute for Advanced Life Sciences, Hoshi University, 2.Graduate school of Pharmaceutical Sciences, Hoshi University)
キーテクノロジー：プロテオミクス
[3S11m-05]Dominant negative OTULIN-related autoinflammatory syndrome
○Yuri Shibata1, David Komander2 (1.Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2.Walter and Eliza Hall Institute of Medical Research)
キーテクノロジー：WGS, DUB assay
[3S11m-06]Elucidation of the molecular mechanism by which USP8 inhibits lentiviral particle formation
○Kenta Hagiuda1, Yuya Himi1, Keijun Kakihara2, Masayuki Komada1,2, Fukushima Toshiaki1,2 (1.School of Life Science and Technology, Institute of Science Tokyo, 2.Institute of Integrated Research, Institute of Science Tokyo)
キーテクノロジー：RT-qPCR
[3S11m-07]Identification of the appropriate DUB for the rescue of misfolded CFTR
○Tsukasa Okiyoneda (Dept Biomed Sci, Kwansei Gakuin Univ)
キーテクノロジー：HiBiT, HRP assay
[3S11m-08]Development of inhibitors of deubiquitinating enzyme of Crimean-Congo hemorrhagic fever virus
○Hirotaka Takahashi1, Kurumi Higoshi1, Shinichi Terawaki2, Yoshinori Taguchi3, Kazuma Takeda4, Tetsuo Narumi3,4, Yusuke Sato5, Naoki Sakai6, Kazuyoshi Ikeda7, Kentaro Tomii8, Daisuke Oikawa9, Fuminori Tokunaga9,10, Minato Hirano11, Kentaro Yoshii11, Tatsuya Sawasaki1 (1.Div. of Cell-free Sci., PROS, Ehime Univ., 2.Div. of Struct. Ana. of Prot. Comp., PROS, Ehime Univ., 3.Coop. Major in Med. Photonics, Grad. Sch. of Med. Photonics, Shizuoka Univ., 4.Dept. of Eng., Grad. Sch. of Integrated Sci. & Tech, Shizuoka Univ., 5.Dept. of Chem. Biol., Grad. Sch. of Eng., Tottori Univ., 6.JASRI, 7.RIKEN R-CCS, 8.AIRC, AIST, 9.Dept. of Med. Biochem., Grad. Sch. of Med., Osaka Metropol. Univ., 10.Res. Inst. for Drug Discov. Sci., Osaka Metropol. Univ., 11.CCPID, Nagasaki Univ.)
キーテクノロジー：DUB阻害剤開発プラットフォーム