[3T03] Biology of Diseases 04 | The 98th Annual Meeting of the Japanese Biochemical Society

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[3T03]Biology of Diseases 04

Wed. Nov 5, 2025 10:50 AM - 11:50 AM JST
Wed. Nov 5, 2025 1:50 AM - 2:50 AM UTC

Room3(Room B-1)

Organizers：Kazuhiro Nakaso（Tottori University）, Toshiki Itoh（Biosignal Research Center, Kobe University）

10:50 AM - 11:00 AM JST(1:50 AM - 2:00 AM UTC)

[3T03-01]Development of a high-affinity ligand for mutant vitamin D receptors causing type II rickets and evaluation of its therapeutic effects in a rat model

^○Souma Murata¹, Yuuki Okamoto¹, Hiroki Mano¹, Fumihiro Kawagoe², Astushi Kittaka³, Sayuri Mototani³, Toshiyuki Sakaki¹, Kaori Yasuda¹ (1.Toyama Prefectural University, 2.Tokyo University of Science, 3.Teikyo University)

キーテクノロジー：1,25D3誘導体による骨形成評価

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11:00 AM - 11:10 AM JST(2:00 AM - 2:10 AM UTC)

[3T03-02]Decreased hepatic zinc promotes lipid accumulation via reduction of H3K14 acetylation

^○Satoshi Takenaka¹, Takao Fujisawa^1,2, Hidenori Ichijo¹ (1.Advanced Research Departments, Institute of Science Tokyo, 2.Graduate School of Pharmaceutical Sciences, The University of Tokyo)

キーテクノロジー：RNA-seq

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11:10 AM - 11:20 AM JST(2:10 AM - 2:20 AM UTC)

[3T03-03]Mechanism of visceral pain regulation focusing on nerve-associated macrophages

^○Tatsuhide Tanaka¹, Ye Mun Aung¹, Akio Wanaka² (1.National Center for Geriatrics and Gerontology, 2.Jikei University of Health Care Sciences)

キーテクノロジー：免疫染色

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11:20 AM - 11:30 AM JST(2:20 AM - 2:30 AM UTC)

[3T03-04]LRBA promotes drug-induced liver injury and MASLD by scaffolding MAPK activation

^○Daisuke Oikawa¹, Yoshinori Okina¹, Min Gi², Minh Duc Pham³, Thi Thanh Thuy Le⁴, Yusuke Sato⁵, Hidetaka Kosako⁶, Hiroko Ikenaga³, Tsutomu Matsubara⁷, Hirotaka Takahashi⁸, Takuro Horii⁹, Izuho Hatada⁹, Tatsuya Sawasaki⁸, Norifumi Kawada³, Fuminori Tokunaga^1,10 (1.Dept. of Med. Biochem., Grad. Sch. of Med., Osaka Metropol. Univ., 2.Dept. of Environ. Risk Aces., Grad. Sch. of Med., Osaka Metropol. Univ., 3.Dept. of Hepatol., Grad. Sch. of Med., Osaka Metropol. Univ., 4.Dept. of Glob. Edu. Med. Sci., Grad. Sch. of Med., Osaka Metropol. Univ., 5.Dept. of Chem. Biol., Grad. Sch. of Eng., Tottori Univ., 6.Inst. of Adv. Med. Sci., Tokushima Univ., 7.Dept. of Anat. Regen. Biol., Grad. Sch. of Med., Osaka Metropol. Univ., 8.PROS, Ehime. Univ., 9.Lab. of Genome Sci., Inst. for Mol. Cell. Res., Gunma Univ., 10.Res. Inst. for Drug Discov. Sci., Osaka Metropol. Univ.)

キーテクノロジー：single cell fixed RNA-seq

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11:30 AM - 11:40 AM JST(2:30 AM - 2:40 AM UTC)

[3T03-05]Function and gene expression of Neuregulin1, a liver-derived secretory factor, essential for compensatory islet hyperplasia in Type 2 diabetes

^○Nobuhito Goda (Waseda University, Faculty of Science and Engineering)

キーテクノロジー：遺伝子改変

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11:40 AM - 11:50 AM JST(2:40 AM - 2:50 AM UTC)

[3T03-06]Functional analysis of orphan GPCRs expressed in liver

^○Karin Hamazume¹, Yoshimi Miki², Kei Yamamoto² (1.Graduate School of Sciences and Technology for Innovation, Bioresource Science, Tokushima University, Tokushima, Japan, 2.Division of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan)

キーテクノロジー：遺伝子改変マウス

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