[20p-A305-1~23] 3.3 Biomedical optics (formerly 3.4)

3:30 PM - 3:45 PM JST(6:30 AM - 6:45 AM UTC)Presentation by Applicant for JSAP Young Scientists Presentation Award

[20p-A305-10] Mid-infrared microscopy with a 125-nm spatial resolution

〇Keiichiro Toda¹, Miu Tamamitsu¹, Venkata Ramaiah Badarla¹, Hiroyuki Shimada¹, Kuniaki Konishi¹, Takuro Ideguchi¹ (1.The Univ. of Tokyo)

Keywords:

microscopy,mid-infrared,quantitative phase imaging

Mid-infrared photothermal (MIP) microscopy enhances the spatial resolution of mid-infrared (MIR) microscopy by a factor of ten through a combination with visible light, which enables detailed chemical analysis of specimens, such as biological samples. However, the the full potential of its spatial resolving power has not been realized due to the degradation of spatial resolution arising from heat diffusion. In this study, we establish optimal implementation of MIP microscopy to achieve high spatial resolution, taking into account an optimized configuration of the visible microscopy, and the pulse durations of MIR and visible light. Consequently, we domonstrate MIR imaging with a 125-nm resolution, one of the best spatial resolutions among far-field MIR microscopy, with a 60-fold faster acquisition rate compared to existing techniques.