[20p-A305-1~23] 3.3 Biomedical optics (formerly 3.4)

4:30 PM - 4:45 PM JST(7:30 AM - 7:45 AM UTC)Presentation by Applicant for JSAP Young Scientists Presentation Award

[20p-A305-13] Second-Harmonic Generation Polarization Microscopy to Analyze Ultra-Early-Stage Liver Fibrosis in Human Non-Alcoholic Fatty Liver Disease

〇(M2)Tomohiro Tamaki¹, Takeo Minamikawa², Eiji Hase², Mayuko Shimizu³, Yuki Morimoto³, Akihiro Suzuki², Takeshi Yasui², Satoko Nakamura⁴, Akemi Tsutsui⁴, Koichi Takaguchi⁴, Koichi Tsuneyama^2,3 (1.Grad. Sch. Sci. Tech. Innov., Tokushima Univ., 2.pLED, Tokushima Univ., 3.Grad. Sch. Med. Sci., Tokushima Univ., 4.Kagawa Pref. Central Hosp.)

Keywords:

second harmonic generation,non-alcoholic fatty liver disease,fibrosis

Non-alcoholic fatty liver disease (NAFLD) is associated with the chronic progression of fibrosis. Our previous study has shown the feasibility of SHG microscopy for assessing liver fibrosis in NAFLD patients, including the ultra-early stage of liver fibrosis, and the possibility of classifying NAFLD in the ultra-early stage in more detail. In this study, we focused on the feature that SHG intensity is highly dependent on the relationship between the direction of polarization of the incident laser and the collagen orientation direction and aimed at a more detailed staging of the ultra-early stage of NAFLD based on the collagen orientation of liver fibrosis by SHG polarization microscopy.