[20p-A305-1~23] 3.3 Biomedical optics (formerly 3.4)

3:00 PM - 3:15 PM JST(6:00 AM - 6:15 AM UTC)

[20p-A305-8] Discrimination of stroke pathology from blood by FTIR-ATR spectroscopy

〇Saiko Kino¹, Tomohisa Ishida², Masayuki Kanamori², Kuniyasu Niizuma^1,2, Teiji Tominaga², Yuji Matsuura¹ (1.Graduate School of Biomedical Engineering, Tohoku Univ., 2.Graduate School of Medicine, Tohoku Univ.)

Keywords:

FTIR-ATR,PLS Discrimination,Blood biomarkers

We obtained mid-infrared attenuated total reflection (FTIR-ATR) spectra of plasma samples from 44 patients with cerebral hemorrhage, 48 patients with cerebral infarction, and 53 healthy subjects, and used partial least squares (PLS) analysis to discriminate between patients with and without stroke, and to predict the severity of stroke and its pathological state. We achieved 94% accuracy in discriminating normal subjects from stroke subjects and 79% accuracy in discriminating cerebral hemorrhage from cerebral infarction, and also showed predictability of ischemic foci volume in cerebral infarction. We estimated candidate blood biomarkers for stroke based on the number of absorbed waves, which is highly important for discrimination and prediction.