Presentation Information
[21p-D902-3]Difference in LSPR sensitivity for detection of α-synuclein amyloid
protein depending on the nanostructure geometry
〇Yuto Kimura1, Carl Frederik Werner1, Minoru Takeda1, Masayuki Fukuzawa2, Minoru Noda1 (1.Electronics,Kyoto inst. tech., 2.Information science,Kyoto inst. tech.)
Keywords:
LSPR,alpha synuclein,Parkinson's disease
The amyloid protein α-synuclein (αSyn) is thought to be a causative agent of Parkinson's disease (PD) by aggregation and fibrillization. We previously fabricated a localized surface plasmon resonance (LSPR) sensor to detect αSyn aggregates for the purpose of ultra-early diagnosis of PD and confirmed its detection. In this study, based on the results of the previous study, we investigated the difference in detectability for αSyn depending on the geometry of the nanostructure of the LSPR sensor.