[17a-D62-1~7] 2.4 Medical application

10:30 AM - 10:45 AM JST(1:30 AM - 1:45 AM UTC)

[17a-D62-3] Development of high-sensitivity Compton camera for Lu-177 radioactive contamination imaging

〇(D)Hikari Tsukamoto^1,5, Hiroshi Muraishi¹, Ryoji Enomoto¹, Hideaki Katagiri², Mika Kagaya³, Takara Watanabe¹, Daisuke Kano⁴, Takahiro Mizoguchi¹, Masaya Fukumoto¹, Yusuke Watanabe¹ (1.Kitasato Univ., 2.Ibaraki Univ., 3.NIT, Sendai Col., 4.NCCHE, 5.Tokai Univ. Hosp)

Keywords:

radionuclide therapy,radioactive contamination,Compton camera

Lutetium-oxodotreotide (Lu-177) is a radiopharmaceutical used for peptide receptor radionuclide therapy (PRRT) in treating neuroendocrine tumors. Approved in Japan in 2021, it was the first PRRT drug in the country. With a half-life of 6.73 d, Lu-177 emits gamma rays of 113 and 208 keV as well as beta rays of 176, 385, and 498 keV. Lu-177 treatment injects a radioactivity of 7.4 GBq per session into the patient, 70% of which is excreted through urine within 48 h. Given this, monitoring Lu-177 in the environment of the medical facilities is essential to minimize the exposure of medical staff to radioactivity. In this study, we developed a Compton camera capable of visualizing 100–200 keV gamma rays emitted by Lu-177 with high sensitivity.