Presentation Information
[22a-P03-12]Development of an efficient fabrication process for devices that allow the application of lateral voltages in an artificial cell membrane system
〇Tatsuya Nomoto1,2, Maki Komiya1, Shunsuke Nomura1,3, Teng Ma4, Daisuke Tadaki1, Hideaki Yamamoto1, Yuzuru Tozawa5, Ayumi Hirano1,2,4 (1.RIEC, Tohoku Univ, 2.Grad. Sch. Biomed. Eng., Tohoku Univ., 3.Grad. Sch. Eng., Tohoku Univ., 4.WPI-AIMR, Tohoku Univ., 5.Grad. Sch. Sci. Tech. Saitama Univ.)
Keywords:
Electrophysiology,Artificial cell membrane,Ion channel
Recently, we have reported that once deactivated human potential-dependent Na ion channels can be reactivated by also applying a lateral membrane voltage, indicating that lateral membrane voltage may be an important new parameter for ion channel activation. However, the short lifetime of the Ti electrode (<30 min) due to oxidation and the instability of the insulating layer due to cracks in the SiO2 film layer are major barriers in conducting experiments on devices in which lateral membrane voltage is applied. In this study, we aimed to develop a highly efficient fabrication process for longer-lived and more stable devices that overcomes these drawbacks.