Presentation Information
[23p-P02-16]Metal-polyphenol complex nanoparticles for a controlled release of anticancer drug
〇(M1)Zihan Gong1, Akari Yamada1, Noritaka Kato1 (1.Meiji Univ.)
Keywords:
emulsification,drug carrier,pH-responsive
The nanoparticle formation of the metal-tannic acid complex and the anticancer drug loading were carried out simultaneously using ultrasonic emulsification. The average diameter of these particles was approximately 67 nm. After suspending these particles in the buffers corresponding to the environments of the normal and cancer cells for 24 hours, the cumulative release amount of the drug was found to be 13 times higher in the latter buffer. The result indicates that nanosized drug carriers that selectively release the anticancer drug in the cancerous environment have been developed.